Integrins and adhesive receptors in normal and leukemic CD34+ progenitor cells: Potential regulatory checkpoints for cellular traffic

Research output: Contribution to journalArticle

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Abstract

Multiple adhesion receptors are involved in the interaction of hematopoietic cells with the marrow microenvironment. This work characterizes the expression of various adhesive receptors on normal early hematopoietic precursors and reviews how they might be altered in leukemic states. Early hematopoietic CD34+ cells express CD18, CD11a, CD49d, CD49e, CD44, ICAM-1, and ICAM-3. Likewise, most AML samples express CD49d, CD49e, and CD44. In addition to mediating the adherence of progenitors to the marrow, these multiple receptors and their respective ligands may serve to regulate in vivo leukemic cell agrees from marrow and the ability of certain leukemic phenotypes to selectively seek extramedullary sanctuary sites such as the skin and the central nervous system.

Original languageEnglish
Pages (from-to)19-28
Number of pages10
JournalLeukemia and Lymphoma
Volume14
Issue number1-2
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Keywords

  • Adhesion
  • Integrin selectin
  • Myeloid leukemia

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