TY - JOUR
T1 - Integrins and adhesive receptors in normal and leukemic CD34+ progenitor cells
T2 - Potential regulatory checkpoints for cellular traffic
AU - Liesveld, Jane L.
AU - Dipersio, John F.
AU - Abboud, Camille N.
N1 - Funding Information:
cellent technical assistance of Todd Belanger, Karen Frediani, Abigail Harbol and Maureen Kempski. This work was supported in part by USPHS Grants KI 1 HL02385 (JLL), HL-18208 (CNA), ROI CA61462 (JFD, CNA) and ROI CA61472 (CNA, JLL).
PY - 1994
Y1 - 1994
N2 - Multiple adhesion receptors are involved in the interaction of hematopoietic cells with the marrow microenvironment. This work characterizes the expression of various adhesive receptors on normal early hematopoietic precursors and reviews how they might be altered in leukemic states. Early hematopoietic CD34+ cells express CD18, CD11a, CD49d, CD49e, CD44, ICAM-1, and ICAM-3. Likewise, most AML samples express CD49d, CD49e, and CD44. In addition to mediating the adherence of progenitors to the marrow, these multiple receptors and their respective ligands may serve to regulate in vivo leukemic cell agrees from marrow and the ability of certain leukemic phenotypes to selectively seek extramedullary sanctuary sites such as the skin and the central nervous system.
AB - Multiple adhesion receptors are involved in the interaction of hematopoietic cells with the marrow microenvironment. This work characterizes the expression of various adhesive receptors on normal early hematopoietic precursors and reviews how they might be altered in leukemic states. Early hematopoietic CD34+ cells express CD18, CD11a, CD49d, CD49e, CD44, ICAM-1, and ICAM-3. Likewise, most AML samples express CD49d, CD49e, and CD44. In addition to mediating the adherence of progenitors to the marrow, these multiple receptors and their respective ligands may serve to regulate in vivo leukemic cell agrees from marrow and the ability of certain leukemic phenotypes to selectively seek extramedullary sanctuary sites such as the skin and the central nervous system.
KW - Adhesion
KW - Integrin selectin
KW - Myeloid leukemia
UR - http://www.scopus.com/inward/record.url?scp=0028360830&partnerID=8YFLogxK
U2 - 10.3109/10428199409049647
DO - 10.3109/10428199409049647
M3 - Article
C2 - 7522718
AN - SCOPUS:0028360830
SN - 1042-8194
VL - 14
SP - 19
EP - 28
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 1-2
ER -