Integrative Genomic Profiling of Human Prostate Cancer

Barry S. Taylor, Nikolaus Schultz, Haley Hieronymus, Anuradha Gopalan, Yonghong Xiao, Brett S. Carver, Vivek K. Arora, Poorvi Kaushik, Ethan Cerami, Boris Reva, Yevgeniy Antipin, Nicholas Mitsiades, Thomas Landers, Igor Dolgalev, John E. Major, Manda Wilson, Nicholas D. Socci, Alex E. Lash, Adriana Heguy, James A. EasthamHoward I. Scher, Victor E. Reuter, Peter T. Scardino, Chris Sander, Charles L. Sawyers, William L. Gerald

Research output: Contribution to journalArticle

2232 Scopus citations

Abstract

Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuclear receptor coactivator NCOA2 as an oncogene in ∼11% of tumors. Additionally, the androgen-driven TMPRSS2-ERG fusion was associated with a previously unrecognized, prostate-specific deletion at chromosome 3p14 that implicates FOXP1, RYBP, and SHQ1 as potential cooperative tumor suppressors. DNA copy-number data from primary tumors revealed that copy-number alterations robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. The genomic and clinical outcome data from these patients are now made available as a public resource.

Original languageEnglish
Pages (from-to)11-22
Number of pages12
JournalCancer Cell
Volume18
Issue number1
DOIs
StatePublished - Jul 1 2010
Externally publishedYes

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    Taylor, B. S., Schultz, N., Hieronymus, H., Gopalan, A., Xiao, Y., Carver, B. S., Arora, V. K., Kaushik, P., Cerami, E., Reva, B., Antipin, Y., Mitsiades, N., Landers, T., Dolgalev, I., Major, J. E., Wilson, M., Socci, N. D., Lash, A. E., Heguy, A., ... Gerald, W. L. (2010). Integrative Genomic Profiling of Human Prostate Cancer. Cancer Cell, 18(1), 11-22. https://doi.org/10.1016/j.ccr.2010.05.026