@article{ed8cb21e8b674a1abb29b2e81aa43ea1,
title = "Integration of Light and Photoperiodic Signaling in Transcriptional Nuclear Foci",
abstract = "Light regulates major plant developmental transitions by orchestrating a series of nuclear events. This study uncovers the molecular function of the natural variant, TZP (Tandem Zinc-finger-Plus3), as a signal integrator of light and photoperiodic pathways in transcriptional nuclear foci. We report that TZP acts as a positive regulator of photoperiodic flowering via physical interactions with the red-light receptor phytochrome B (phyB). We demonstrate that TZP localizes in dynamic nuclear domains regulated by light quality and photoperiod. This study shows that phyB is indispensable not only for localizing TZP to transcriptionally active nuclear photobodies, but also for recruiting TZP on the promoter of the floral inducer FLOWERING LOCUS T (FT). Our findings signify a unique transcriptional regulatory role to the highly enigmatic plant nuclear photobodies, where TZP directly activates FT gene expression and promotes flowering.",
author = "Eirini Kaiserli and Katalin P{\'a}ldi and Liz O'Donnell and Olga Batalov and Pedmale, {Ullas V.} and Nusinow, {Dmitri A.} and Kay, {Steve A.} and Joanne Chory",
note = "Funding Information: We are grateful to Dr. James Fitzpatrick, (Salk Institute) for advice on FRAP measurements and to Dr. Yvon Jaillais (Lyon) for providing plasmids containing 35S pro , UBI10 pro , mCITRINE, and mCHERRY. We are grateful to Prof. Peter Shaw (JIC) for the gift of coilin-RFP, Prof. Akira Nagatani (Tokyo) for his gift of anti-PHYB antibody, and Prof. Young-Tae Chang (Singapore) for the RNA selective probes. Many thanks to Prof. Ferenc Nagy (Edinburgh) and Prof. Eberhard Sch{\"a}fer (Freiburg) for sharing data and helpful discussions, Dr. Lucio Conti (Milan) and Dr. Doris Lucyshyn (Vienna) for advice on flowering experiments, and Dr. Stuart Sullivan (Glasgow) for providing the ISU primers. We thank Prof. John Christie and Dr. Stuart Sullivan for critically reading the manuscript. The early stages of this work were supported by the NIH grant R01-GM52413 and the Howard Hughes Medical Institute (to J.C.). J.C. is an investigator at the Howard Hughes Medical Institute. E.K. was supported by fellowships from the Human Frontier Science Program, the Salk Institute (Pioneer Fund, Kirby and Stern Foundations) and the University of Glasgow (Lord Kelvin and Adam Smith Fellowship). D.A.N. and S.A.K. acknowledge support from the National Institutes of Health (NRSA GM083585 to D.A.N., and R01 GM050006 and GM067837 to S.A.K.). Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = nov,
day = "9",
doi = "10.1016/j.devcel.2015.10.008",
language = "English",
volume = "35",
pages = "311--321",
journal = "Developmental Cell",
issn = "1534-5807",
number = "3",
}