TY - JOUR
T1 - Integrating tuberculosis screening in Kenyan Prevention of Mother-To-Child Transmission programs
AU - Cranmer, L. M.
AU - Langat, A.
AU - Ronen, K.
AU - McGrath, C. J.
AU - LaCourse, S.
AU - Pintye, J.
AU - Odeny, B.
AU - Singa, B.
AU - Katana, A.
AU - Nganga, L.
AU - Kinuthia, J.
AU - John-Stewart, G.
N1 - Publisher Copyright:
© 2017 The Union.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - BACKGROUND: Tuberculosis (TB) screening in Prevention of Mother-To-Child Transmission (PMTCT) programs is important to improve TB detection, prevention and treatment. METHODS : As part of a national PMTCT program evaluation, mother-infant pairs attending 6-week and 9-month immunization visits were enrolled at 141 maternal and child health clinics throughout Kenya. Clinics were selected using population-proportion-tosize sampling with oversampling in a high human immunodeficiency virus (HIV) prevalence region. The World Health Organization (WHO) TB symptom screen was administered to HIV-infected mothers, and associations with infant cofactors were determined. R E SULT S : Among 498 HIV-infected mothers, 165 (33%) had a positive TB symptom screen. Positive maternal TB symptom screen was associated with prior TB (P 0.04). Women with a positive TB symptom screen were more likely to have an infant with HIV infection (P 0.02) and non-specific TB symptoms, including cough (P 0.003), fever (P 0.05), and difficulty breathing (P 0.01). TB exposure was reported by 11% of the women, and 15% of the TBexposed women received isoniazid preventive therapy. CONCLUS IONS : Postpartum HIV-infected mothers frequently had a positive TB symptom screen. Mothers with a positive TB symptom screen were more likely to have infants with HIV or non-specific TB symptoms. Integration of maternal TB screening and prevention into PMTCT programs may improve maternal and infant outcomes.
AB - BACKGROUND: Tuberculosis (TB) screening in Prevention of Mother-To-Child Transmission (PMTCT) programs is important to improve TB detection, prevention and treatment. METHODS : As part of a national PMTCT program evaluation, mother-infant pairs attending 6-week and 9-month immunization visits were enrolled at 141 maternal and child health clinics throughout Kenya. Clinics were selected using population-proportion-tosize sampling with oversampling in a high human immunodeficiency virus (HIV) prevalence region. The World Health Organization (WHO) TB symptom screen was administered to HIV-infected mothers, and associations with infant cofactors were determined. R E SULT S : Among 498 HIV-infected mothers, 165 (33%) had a positive TB symptom screen. Positive maternal TB symptom screen was associated with prior TB (P 0.04). Women with a positive TB symptom screen were more likely to have an infant with HIV infection (P 0.02) and non-specific TB symptoms, including cough (P 0.003), fever (P 0.05), and difficulty breathing (P 0.01). TB exposure was reported by 11% of the women, and 15% of the TBexposed women received isoniazid preventive therapy. CONCLUS IONS : Postpartum HIV-infected mothers frequently had a positive TB symptom screen. Mothers with a positive TB symptom screen were more likely to have infants with HIV or non-specific TB symptoms. Integration of maternal TB screening and prevention into PMTCT programs may improve maternal and infant outcomes.
KW - HIV
KW - PMTCT
KW - Tuberculosis screening
UR - https://www.scopus.com/pages/publications/85015232362
U2 - 10.5588/ijtld.16.0478
DO - 10.5588/ijtld.16.0478
M3 - Article
C2 - 28225335
AN - SCOPUS:85015232362
SN - 1027-3719
VL - 21
SP - 256
EP - 262
JO - International Journal of Tuberculosis and Lung Disease
JF - International Journal of Tuberculosis and Lung Disease
IS - 3
ER -