Integrating immunometabolism and macrophage diversity

Maxim N. Artyomov, Alexey Sergushichev, Joel D. Schilling

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations

Abstract

Macrophages are heterogeneous cells that play a key role in inflammatory and tissue reparative responses. Over the past decade it has become clear that shifts in cellular metabolism are important determinants of macrophage function and phenotype. At the same time, our appreciation of macrophage diversity in vivo has also been increasing. Factors such as cell origin and tissue localization are now recognized as important variables that influence macrophage biology. Whether different macrophage populations also have unique metabolic phenotypes has not been extensively explored. In this article, we will discuss the importance of understanding how macrophage origin can modulate metabolic programming and influence inflammatory responses.

Original languageEnglish
Pages (from-to)417-424
Number of pages8
JournalSeminars in immunology
Volume28
Issue number5
DOIs
StatePublished - Oct 1 2016

Keywords

  • Glycolysis
  • Inflammation
  • Metabolism
  • Mitochondria
  • Nitric oxide

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