Integrating ethics and science in the International HapMap Project

Morris W. Foster, Ellen Wright Clayton, Bartha M. Knoppers, Renzong Qiu, Alastair Kent, Georgia M. Dunston, Kazuto Kato, Norio Niikawa, Isaac F. Adewole, Jessica Watkin, Houcan Zhang, Changqing Zeng, Ichiro Matsuda, Yoshimitsu Fukushima, Darryl R. Macer, Eiko Suda, Charles N. Rotimi, Clement A. Adebamowo, Toyin Aniagwu, Patricia A. MarshallOlayemi Matthew, Chibuzor Nkwodimmah, Charmaine D.M. Royal, Mark F. Leppert, Missy Dixon, David L. Valle, Lynn B. Jorde, John W. Belmont, Aravinda Chakravarti, Mildred K. Cho, Troy Duster, Marla Jasperse, Pui Yan Kwok, Julio Licinio, Jeffrey C. Long, Pilar N. Ossorio, Vivian Ota Wang, Patricia Spallone, Sharon F. Terry, Richard A. Gibbs, Paul Hardenbol, Thomas D. Willis, Fuli Yu, David Altshuler, Stacey B. Gabriel, Huanming Yang, Lan Yang Ch'ang, Wei Huang, Bin Liu, Yan Shen, Paul Kwong Hang Tam, Lap Chee Tsui, Mary Miu Yee Waye, Jeffrey Tze Fei Wong, Qingrun Zhang, Mark S. Chee, Luana M. Galver, Semyon Kruglyak, Sarah S. Murray, Arnold R. Oliphant, Alexandre Montpetit, Thomas J. Hudson, Fanny Chagnon, Vincent Ferretti, Martin Leboeuf, Michael S. Phillips, Andrei Verner, Shenghui Duan, Denise L. Lind, Raymond D. Miller, John P. Rice, Nancy L. Saccone, Patricia Taillon-Miller, Ming Xiao, Yusuke Nakamura, Akihiro Sekine, Koki Sorimachi, Toshihiro Tanaka, Yoichi Tanaka, Tatsuhiko Tsunoda, Eiji Yoshino, David R. Bentley, Panos Deloukas, Don Powell, Mark J. Daly, Stephen F. Schaffner, Lincoln D. Stein, Fiona Cunningham, Ardavan Kanani, Gudmundur A. Thorisson, Peter E. Chen, David J. Cutler, Carl S. Kashuk, Shin Lin, Peter Donnelly, Jonathan Marchini, Gilean A.T. McVean, Simon R. Myers, Lon R. Cardon, Gonçalo R. Abecasis, Andrew Morris, Bruce S. Weir, James C. Mullikin, Stephen T. Sherry, Michael Feolo, Erica Sodergren, George M. Weinstock, Bruce W. Birren, Richard K. Wilson, Lucinda L. Fulton, Jane Rogers, Hua Han, Hongguang Wang, Martin Godbout, John C. Wallenburg, Paul L'Archevêque, Guy Bellemare, Kazuo Todani, Takashi Fujita, Satoshi Tanaka, Arthur L. Holden, Eric H. Lai, Francis S. Collins, Jean E. McEwen, Lisa D. Brooks, Mark S. Guyer, Elke Jordan, Jane L. Peterson, Jack Spiegel, Lawrence M. Sung, Lynn F. Zacharia, Karen Kennedy, Michael G. Dunn, Richard Seabrook, Mark Shillito, Barbara Skene, John G. Stewart, Eric S. Lander, Deborah A. Nickerson, Michael Boehnke, Julie A. Douglas, Richard R. Hudson, Leonid Kruglyak, Robert L. Nussbaum

Research output: Contribution to journalReview article

184 Scopus citations

Abstract

Genomics resources that use samples from identified populations raise scientific, social and ethical issues that are, in many ways, inextricably linked. Scientific decisions about which populations to sample to produce the HapMap, an international genetic vadation resource, have raised questions about the relationships between the social identities used to recruit participants and the biological findings of studies that will use the HapMap. The sometimes problematic implications of those complex relationships have led to questions about how to conduct genetic variation research that uses identified populations in an ethical way, including how to involve members of a population in evaluating the risks and benefits posed for everyone who shares that identity. The ways in which these issues are linked is increasingly drawing the scientific and ethical spheres of genomics research closer together.

Original languageEnglish
Pages (from-to)467-475
Number of pages9
JournalNature Reviews Genetics
Volume5
Issue number6
DOIs
StatePublished - Jun 1 2004
Externally publishedYes

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    Foster, M. W., Clayton, E. W., Knoppers, B. M., Qiu, R., Kent, A., Dunston, G. M., Kato, K., Niikawa, N., Adewole, I. F., Watkin, J., Zhang, H., Zeng, C., Matsuda, I., Fukushima, Y., Macer, D. R., Suda, E., Rotimi, C. N., Adebamowo, C. A., Aniagwu, T., ... Nussbaum, R. L. (2004). Integrating ethics and science in the International HapMap Project. Nature Reviews Genetics, 5(6), 467-475. https://doi.org/10.1038/nrg1351