Abstract
Genomics resources that use samples from identified populations raise scientific, social and ethical issues that are, in many ways, inextricably linked. Scientific decisions about which populations to sample to produce the HapMap, an international genetic vadation resource, have raised questions about the relationships between the social identities used to recruit participants and the biological findings of studies that will use the HapMap. The sometimes problematic implications of those complex relationships have led to questions about how to conduct genetic variation research that uses identified populations in an ethical way, including how to involve members of a population in evaluating the risks and benefits posed for everyone who shares that identity. The ways in which these issues are linked is increasingly drawing the scientific and ethical spheres of genomics research closer together.
Original language | English |
---|---|
Pages (from-to) | 467-475 |
Number of pages | 9 |
Journal | Nature Reviews Genetics |
Volume | 5 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1 2004 |
Externally published | Yes |
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Integrating ethics and science in the International HapMap Project. / Foster, Morris W.; Clayton, Ellen Wright; Knoppers, Bartha M.; Qiu, Renzong; Kent, Alastair; Dunston, Georgia M.; Kato, Kazuto; Niikawa, Norio; Adewole, Isaac F.; Watkin, Jessica; Zhang, Houcan; Zeng, Changqing; Matsuda, Ichiro; Fukushima, Yoshimitsu; Macer, Darryl R.; Suda, Eiko; Rotimi, Charles N.; Adebamowo, Clement A.; Aniagwu, Toyin; Marshall, Patricia A.; Matthew, Olayemi; Nkwodimmah, Chibuzor; Royal, Charmaine D.M.; Leppert, Mark F.; Dixon, Missy; Valle, David L.; Jorde, Lynn B.; Belmont, John W.; Chakravarti, Aravinda; Cho, Mildred K.; Duster, Troy; Jasperse, Marla; Kwok, Pui Yan; Licinio, Julio; Long, Jeffrey C.; Ossorio, Pilar N.; Wang, Vivian Ota; Spallone, Patricia; Terry, Sharon F.; Gibbs, Richard A.; Hardenbol, Paul; Willis, Thomas D.; Yu, Fuli; Altshuler, David; Gabriel, Stacey B.; Yang, Huanming; Ch'ang, Lan Yang; Huang, Wei; Liu, Bin; Shen, Yan; Tam, Paul Kwong Hang; Tsui, Lap Chee; Waye, Mary Miu Yee; Wong, Jeffrey Tze Fei; Zhang, Qingrun; Chee, Mark S.; Galver, Luana M.; Kruglyak, Semyon; Murray, Sarah S.; Oliphant, Arnold R.; Montpetit, Alexandre; Hudson, Thomas J.; Chagnon, Fanny; Ferretti, Vincent; Leboeuf, Martin; Phillips, Michael S.; Verner, Andrei; Duan, Shenghui; Lind, Denise L.; Miller, Raymond D.; Rice, John P.; Saccone, Nancy L.; Taillon-Miller, Patricia; Xiao, Ming; Nakamura, Yusuke; Sekine, Akihiro; Sorimachi, Koki; Tanaka, Toshihiro; Tanaka, Yoichi; Tsunoda, Tatsuhiko; Yoshino, Eiji; Bentley, David R.; Deloukas, Panos; Powell, Don; Daly, Mark J.; Schaffner, Stephen F.; Stein, Lincoln D.; Cunningham, Fiona; Kanani, Ardavan; Thorisson, Gudmundur A.; Chen, Peter E.; Cutler, David J.; Kashuk, Carl S.; Lin, Shin; Donnelly, Peter; Marchini, Jonathan; McVean, Gilean A.T.; Myers, Simon R.; Cardon, Lon R.; Abecasis, Gonçalo R.; Morris, Andrew; Weir, Bruce S.; Mullikin, James C.; Sherry, Stephen T.; Feolo, Michael; Sodergren, Erica; Weinstock, George M.; Birren, Bruce W.; Wilson, Richard K.; Fulton, Lucinda L.; Rogers, Jane; Han, Hua; Wang, Hongguang; Godbout, Martin; Wallenburg, John C.; L'Archevêque, Paul; Bellemare, Guy; Todani, Kazuo; Fujita, Takashi; Tanaka, Satoshi; Holden, Arthur L.; Lai, Eric H.; Collins, Francis S.; McEwen, Jean E.; Brooks, Lisa D.; Guyer, Mark S.; Jordan, Elke; Peterson, Jane L.; Spiegel, Jack; Sung, Lawrence M.; Zacharia, Lynn F.; Kennedy, Karen; Dunn, Michael G.; Seabrook, Richard; Shillito, Mark; Skene, Barbara; Stewart, John G.; Lander, Eric S.; Nickerson, Deborah A.; Boehnke, Michael; Douglas, Julie A.; Hudson, Richard R.; Kruglyak, Leonid; Nussbaum, Robert L.
In: Nature Reviews Genetics, Vol. 5, No. 6, 01.06.2004, p. 467-475.Research output: Contribution to journal › Review article › peer-review
TY - JOUR
T1 - Integrating ethics and science in the International HapMap Project
AU - Foster, Morris W.
AU - Clayton, Ellen Wright
AU - Knoppers, Bartha M.
AU - Qiu, Renzong
AU - Kent, Alastair
AU - Dunston, Georgia M.
AU - Kato, Kazuto
AU - Niikawa, Norio
AU - Adewole, Isaac F.
AU - Watkin, Jessica
AU - Zhang, Houcan
AU - Zeng, Changqing
AU - Matsuda, Ichiro
AU - Fukushima, Yoshimitsu
AU - Macer, Darryl R.
AU - Suda, Eiko
AU - Rotimi, Charles N.
AU - Adebamowo, Clement A.
AU - Aniagwu, Toyin
AU - Marshall, Patricia A.
AU - Matthew, Olayemi
AU - Nkwodimmah, Chibuzor
AU - Royal, Charmaine D.M.
AU - Leppert, Mark F.
AU - Dixon, Missy
AU - Valle, David L.
AU - Jorde, Lynn B.
AU - Belmont, John W.
AU - Chakravarti, Aravinda
AU - Cho, Mildred K.
AU - Duster, Troy
AU - Jasperse, Marla
AU - Kwok, Pui Yan
AU - Licinio, Julio
AU - Long, Jeffrey C.
AU - Ossorio, Pilar N.
AU - Wang, Vivian Ota
AU - Spallone, Patricia
AU - Terry, Sharon F.
AU - Gibbs, Richard A.
AU - Hardenbol, Paul
AU - Willis, Thomas D.
AU - Yu, Fuli
AU - Altshuler, David
AU - Gabriel, Stacey B.
AU - Yang, Huanming
AU - Ch'ang, Lan Yang
AU - Huang, Wei
AU - Liu, Bin
AU - Shen, Yan
AU - Tam, Paul Kwong Hang
AU - Tsui, Lap Chee
AU - Waye, Mary Miu Yee
AU - Wong, Jeffrey Tze Fei
AU - Zhang, Qingrun
AU - Chee, Mark S.
AU - Galver, Luana M.
AU - Kruglyak, Semyon
AU - Murray, Sarah S.
AU - Oliphant, Arnold R.
AU - Montpetit, Alexandre
AU - Hudson, Thomas J.
AU - Chagnon, Fanny
AU - Ferretti, Vincent
AU - Leboeuf, Martin
AU - Phillips, Michael S.
AU - Verner, Andrei
AU - Duan, Shenghui
AU - Lind, Denise L.
AU - Miller, Raymond D.
AU - Rice, John P.
AU - Saccone, Nancy L.
AU - Taillon-Miller, Patricia
AU - Xiao, Ming
AU - Nakamura, Yusuke
AU - Sekine, Akihiro
AU - Sorimachi, Koki
AU - Tanaka, Toshihiro
AU - Tanaka, Yoichi
AU - Tsunoda, Tatsuhiko
AU - Yoshino, Eiji
AU - Bentley, David R.
AU - Deloukas, Panos
AU - Powell, Don
AU - Daly, Mark J.
AU - Schaffner, Stephen F.
AU - Stein, Lincoln D.
AU - Cunningham, Fiona
AU - Kanani, Ardavan
AU - Thorisson, Gudmundur A.
AU - Chen, Peter E.
AU - Cutler, David J.
AU - Kashuk, Carl S.
AU - Lin, Shin
AU - Donnelly, Peter
AU - Marchini, Jonathan
AU - McVean, Gilean A.T.
AU - Myers, Simon R.
AU - Cardon, Lon R.
AU - Abecasis, Gonçalo R.
AU - Morris, Andrew
AU - Weir, Bruce S.
AU - Mullikin, James C.
AU - Sherry, Stephen T.
AU - Feolo, Michael
AU - Sodergren, Erica
AU - Weinstock, George M.
AU - Birren, Bruce W.
AU - Wilson, Richard K.
AU - Fulton, Lucinda L.
AU - Rogers, Jane
AU - Han, Hua
AU - Wang, Hongguang
AU - Godbout, Martin
AU - Wallenburg, John C.
AU - L'Archevêque, Paul
AU - Bellemare, Guy
AU - Todani, Kazuo
AU - Fujita, Takashi
AU - Tanaka, Satoshi
AU - Holden, Arthur L.
AU - Lai, Eric H.
AU - Collins, Francis S.
AU - McEwen, Jean E.
AU - Brooks, Lisa D.
AU - Guyer, Mark S.
AU - Jordan, Elke
AU - Peterson, Jane L.
AU - Spiegel, Jack
AU - Sung, Lawrence M.
AU - Zacharia, Lynn F.
AU - Kennedy, Karen
AU - Dunn, Michael G.
AU - Seabrook, Richard
AU - Shillito, Mark
AU - Skene, Barbara
AU - Stewart, John G.
AU - Lander, Eric S.
AU - Nickerson, Deborah A.
AU - Boehnke, Michael
AU - Douglas, Julie A.
AU - Hudson, Richard R.
AU - Kruglyak, Leonid
AU - Nussbaum, Robert L.
N1 - Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2004/6/1
Y1 - 2004/6/1
N2 - Genomics resources that use samples from identified populations raise scientific, social and ethical issues that are, in many ways, inextricably linked. Scientific decisions about which populations to sample to produce the HapMap, an international genetic vadation resource, have raised questions about the relationships between the social identities used to recruit participants and the biological findings of studies that will use the HapMap. The sometimes problematic implications of those complex relationships have led to questions about how to conduct genetic variation research that uses identified populations in an ethical way, including how to involve members of a population in evaluating the risks and benefits posed for everyone who shares that identity. The ways in which these issues are linked is increasingly drawing the scientific and ethical spheres of genomics research closer together.
AB - Genomics resources that use samples from identified populations raise scientific, social and ethical issues that are, in many ways, inextricably linked. Scientific decisions about which populations to sample to produce the HapMap, an international genetic vadation resource, have raised questions about the relationships between the social identities used to recruit participants and the biological findings of studies that will use the HapMap. The sometimes problematic implications of those complex relationships have led to questions about how to conduct genetic variation research that uses identified populations in an ethical way, including how to involve members of a population in evaluating the risks and benefits posed for everyone who shares that identity. The ways in which these issues are linked is increasingly drawing the scientific and ethical spheres of genomics research closer together.
UR - http://www.scopus.com/inward/record.url?scp=3142773390&partnerID=8YFLogxK
U2 - 10.1038/nrg1351
DO - 10.1038/nrg1351
M3 - Review article
C2 - 15153999
AN - SCOPUS:3142773390
VL - 5
SP - 467
EP - 475
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
SN - 1471-0056
IS - 6
ER -