@article{7cbf2498012848b1b60c6aad18045f1a,
title = "Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer",
abstract = "To provide a detailed analysis of the molecular components and underlying mechanisms associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based proteomic characterization of 174 ovarian tumors previously analyzed by The Cancer Genome Atlas (TCGA), of which 169 were high-grade serous carcinomas (HGSCs). Integrating our proteomic measurements with the genomic data yielded a number of insights into disease, such as how different copy-number alternations influence the proteome, the proteins associated with chromosomal instability, the sets of signaling pathways that diverse genome rearrangements converge on, and the ones most associated with short overall survival. Specific protein acetylations associated with homologous recombination deficiency suggest a potential means for stratifying patients for therapy. In addition to providing a valuable resource, these findings provide a view of how the somatic genome drives the cancer proteome and associations between protein and post-translational modification levels and clinical outcomes in HGSC. Video Abstract.",
author = "{the CPTAC Investigators} and Hui Zhang and Tao Liu and Zhen Zhang and Payne, {Samuel H.} and Bai Zhang and McDermott, {Jason E.} and Zhou, {Jian Ying} and Petyuk, {Vladislav A.} and Li Chen and Debjit Ray and Shisheng Sun and Feng Yang and Lijun Chen and Jing Wang and Punit Shah and Cha, {Seong Won} and Paul Aiyetan and Sunghee Woo and Yuan Tian and Gritsenko, {Marina A.} and Clauss, {Therese R.} and Caitlin Choi and Monroe, {Matthew E.} and Stefani Thomas and Song Nie and Chaochao Wu and Moore, {Ronald J.} and Yu, {Kun Hsing} and Tabb, {David L.} and David Feny{\"o} and V. Vineet and Yue Wang and Henry Rodriguez and Boja, {Emily S.} and Tara Hiltke and Rivers, {Robert C.} and Lori Sokoll and Heng Zhu and Shih, {Ie Ming} and Leslie Cope and Akhilesh Pandey and Bing Zhang and Snyder, {Michael P.} and Levine, {Douglas A.} and Smith, {Richard D.} and Chan, {Daniel W.} and Rodland, {Karin D.} and Carr, {Steven A.} and Li Ding and Townsend, {R. Reid}",
note = "Funding Information: This work was supported by National Cancer Institute (NCI) CPTAC awards U24CA160019 and U24CA160036 and by NIH grant P41GM103493 . The PNNL proteomics work described herein was performed in the Environmental Molecular Sciences Laboratory, a U.S. Department of Energy (DOE) National Scientific User Facility located at PNNL in Richland, WA. PNNL is a multi-program national laboratory operated by the Battelle Memorial Institute for the DOE under contract DE-AC05-76RL01830 . Genomics data for this study were generated by the TCGA Pilot Project, established by the NCI and the National Human Genome Research Institute. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",
year = "2016",
month = jul,
day = "28",
doi = "10.1016/j.cell.2016.05.069",
language = "English",
volume = "166",
pages = "755--765",
journal = "Cell",
issn = "0092-8674",
number = "3",
}