Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

Qiang Gao, Hongwen Zhu, Liangqing Dong, Weiwei Shi, Ran Chen, Zhijian Song, Chen Huang, Junqiang Li, Xiaowei Dong, Yanting Zhou, Qian Liu, Lijie Ma, Xiaoying Wang, Jian Zhou, Yansheng Liu, Emily Boja, Ana I. Robles, Weiping Ma, Pei Wang, Yize LiLi Ding, Bo Wen, Bing Zhang, Henry Rodriguez, Daming Gao, Hu Zhou, Jia Fan

Research output: Contribution to journalArticlepeer-review

218 Scopus citations

Abstract

Proteogenomic characterization of HBV-related hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues identifies three subgroups with distinct features in metabolic reprogramming, microenvironment dysregulation, cell proliferation, and potential therapeutics.

Original languageEnglish
Pages (from-to)561-577.e22
JournalCell
Volume179
Issue number2
DOIs
StatePublished - Oct 3 2019

Keywords

  • AA signature
  • ALDOA
  • CTNNB1
  • hepaotcellular carcinoma
  • metabolism
  • neoantigen
  • prognosis
  • proteogenomics
  • proteomics

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