Integrated electrokinetic lab-on-a-chip based biosensor - A tool for drug screening applications

  • G. Krishnamoorthy
  • , E. T. Carlen
  • , R. B.M. Schasfoort
  • , A. Van Den Berg

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

We report a new integrated Lab-on-a-Chip (LOC) and surface plasmon resonance imaging (iSPR) system that uses electrokinetic (EK) sample transport simultaneously into 10 individual microchannels and 100 sensing locations, where all sensing locations can be measured simultaneously and kinetics and affinity parameters extracted from all the interactant pairs. This new chip can be used for high-throughput drug screening applications and the simultaneous extraction of kinetics and affinity parameters from interactant-protein complex formation.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages581-583
Number of pages3
StatePublished - 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: Oct 3 2010Oct 7 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume1

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Country/TerritoryNetherlands
CityGroningen
Period10/3/1010/7/10

Keywords

  • Biosensor
  • Drug screening
  • Electrokinetics
  • Lab-on-a-chip
  • Surface plasmon resonance imaging

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