Intakes of folate, methionine, vitamin B6, and vitamin B12 with risk of esophageal and gastric cancer in a large cohort study

Q. Xiao, N. D. Freedman, J. Ren, A. R. Hollenbeck, C. C. Abnet, Y. Park

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Background: Nutrients in the one-carbon metabolism pathway may be involved in carcinogenesis. Few cohort studies have investigated the intakes of folate and related nutrients in relation to gastric and esophageal cancer. Methods: We prospectively examined the association between self-reported intakes of folate, methionine, vitamin B6, and vitamin B12 and gastric and esophageal cancer in 492 293 men and women. Results: We observed an elevated risk of esophageal squamous cell carcinoma with low intake of folate (relative risk (95% confidence interval): Q1 vs Q3, 1.91 (1.17, 3.10)), but no association with high intake. Folate intake was not associated with esophageal adenocarcinoma, gastric cardia adenocarcinoma, or non-cardia gastric adenocarcinoma. The intakes of methionine, vitamin B6, and vitamin B12 were not associated with esophageal and gastric cancer. Conclusion: Low intake of folate was associated with increased risk of esophageal squamous cell carcinoma.

Original languageEnglish
Pages (from-to)1328-1333
Number of pages6
JournalBritish Journal of Cancer
Volume110
Issue number5
DOIs
StatePublished - Mar 4 2014

Keywords

  • Esophageal cancer
  • Folate
  • Gastric cancer
  • One-carbon metabolism pathway

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