The development, growth, function and metabolism of the heart are regulated by extracellular growth factors, cytokines and ligands. In this review, the role of insulin and insulin-like growth factors in the regulation of cardiac growth will be discussed. In addition, the role of insulin- and insulin-like growth factor-stimulated intracellular signaling proteins in cardiac growth will be reviewed.

Original languageEnglish
Pages (from-to)855-864
Number of pages10
JournalJournal of Molecular and Cellular Cardiology
Issue number5
StatePublished - May 2008


  • Cardiac growth
  • Diabetes
  • Diabetic cardiomyopathy
  • Heart failure
  • Hypertrophy
  • IGF
  • Insulin
  • Signal transduction
  • Signaling


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