Insulin signaling pathways and cardiac growth

Brian J. DeBosch; Anthony J. Muslin

doi:10.1016/j.yjmcc.2008.03.008

Insulin signaling pathways and cardiac growth

Brian J. DeBosch, Anthony J. Muslin

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

The development, growth, function and metabolism of the heart are regulated by extracellular growth factors, cytokines and ligands. In this review, the role of insulin and insulin-like growth factors in the regulation of cardiac growth will be discussed. In addition, the role of insulin- and insulin-like growth factor-stimulated intracellular signaling proteins in cardiac growth will be reviewed.

Original language	English
Pages (from-to)	855-864
Number of pages	10
Journal	Journal of Molecular and Cellular Cardiology
Volume	44
Issue number	5
DOIs	https://doi.org/10.1016/j.yjmcc.2008.03.008
State	Published - May 2008

Keywords

Cardiac growth
Diabetes
Diabetic cardiomyopathy
Heart failure
Hypertrophy
IGF
Insulin
Signal transduction
Signaling

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10.1016/j.yjmcc.2008.03.008

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title = "Insulin signaling pathways and cardiac growth",

abstract = "The development, growth, function and metabolism of the heart are regulated by extracellular growth factors, cytokines and ligands. In this review, the role of insulin and insulin-like growth factors in the regulation of cardiac growth will be discussed. In addition, the role of insulin- and insulin-like growth factor-stimulated intracellular signaling proteins in cardiac growth will be reviewed.",

keywords = "Cardiac growth, Diabetes, Diabetic cardiomyopathy, Heart failure, Hypertrophy, IGF, Insulin, Signal transduction, Signaling",

author = "DeBosch, {Brian J.} and Muslin, {Anthony J.}",

note = "Funding Information: Work done by the authors cited in this review was supported by grants from the NIH (HL61567, HL057278, HL076670) and the Burroughs Wellcome Fund (A.J. Muslin). B.J. DeBosch was supported by the Cardiovascular Physiology Training Grant T32-HL07873.",

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AU - DeBosch, Brian J.

AU - Muslin, Anthony J.

N1 - Funding Information: Work done by the authors cited in this review was supported by grants from the NIH (HL61567, HL057278, HL076670) and the Burroughs Wellcome Fund (A.J. Muslin). B.J. DeBosch was supported by the Cardiovascular Physiology Training Grant T32-HL07873.

PY - 2008/5

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N2 - The development, growth, function and metabolism of the heart are regulated by extracellular growth factors, cytokines and ligands. In this review, the role of insulin and insulin-like growth factors in the regulation of cardiac growth will be discussed. In addition, the role of insulin- and insulin-like growth factor-stimulated intracellular signaling proteins in cardiac growth will be reviewed.

AB - The development, growth, function and metabolism of the heart are regulated by extracellular growth factors, cytokines and ligands. In this review, the role of insulin and insulin-like growth factors in the regulation of cardiac growth will be discussed. In addition, the role of insulin- and insulin-like growth factor-stimulated intracellular signaling proteins in cardiac growth will be reviewed.

KW - Cardiac growth

KW - Diabetes

KW - Diabetic cardiomyopathy

KW - Heart failure

KW - Hypertrophy

KW - IGF

KW - Insulin

KW - Signal transduction

KW - Signaling

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M3 - Review article

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VL - 44

SP - 855

EP - 864

JO - Journal of Molecular and Cellular Cardiology

JF - Journal of Molecular and Cellular Cardiology

IS - 5

ER -

Insulin signaling pathways and cardiac growth

Abstract

Keywords

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