Insulin release during alpha-adrenergic receptor blockade: Primacy of the glycemic stimulus

Philip E. Cryer, Clifford M. Herman, Jonas Sode

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Insulin release during alphaadrenergic receptor blockade in a variety of experimental animals has raised the possibility of a direct effect of alpha-blockade on insulin secretion. However, in 7 unanesthetized baboons, an increase in the serum insulin concentration during phentolamine-induced alpha-adrenergic receptor blockade occurred only in hyperglycemic animals and the magnitude of the increase in serum insulin was significantly correlated with the serum glucose concentration immediately prior to phentolamine. These findings are consistent with observations showing no effect of alpha-adrenergic inhibitors on basal insulin concentration in (normoglycemic) man and indicate that insulin secretion during alpha-adrenergic receptor blockade occurs only in the presence of an appropriate glycemic stimulus.

Original languageEnglish
Pages (from-to)918-920
Number of pages3
JournalEndocrinology
Volume89
Issue number3
DOIs
StatePublished - Sep 1971
Externally publishedYes

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