Insulin receptor gene polymorphisms (RFLPs) in American Blacks and Pima Indians: an assessment of the use of RFLPs in evaluating a candidate locus for NIDDM

M. A. Permutt, J. McGill, S. C. Elbein, M. Province, C. Bogardus

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

The availability of cloned cDNA for the insulin receptor provides a means for evaluating the role of this gene in the high prevalence of NIDDM in American Blacks and Pima Indians. The frequencies of restriction fragment length polymorphisms (RFLPs) have been measured at this locus in a population of unrelated American Black lean and obese non-insulin dependent diabetics, further subdivided by age of diagnosis. The frequencies of these polymorphisms did not differ from those in a non-diabetic control population. This RFLP analysis was also used to evaluate DNA from 45 non-diabetic Pima Indians who were previously studied by the hyperinsulinemic euglycemic clamp technique. The frequencies of the polymorphic alleles did not differ between a group of low vs high glucose utilizers. A review of recently reported association studies in various racial groups, as well as linkage analysis studies in families, suggests the possibility that the insulin receptor locus may contribute in a minor way to diabetes susceptibility in some racial groups. This hypothesis needs further testing with molecular genetic methods.

Original languageEnglish
Title of host publicationGenes and gene products in the development of diabetes mellitus
Subtitle of host publicationproceedings of the 3rd Nordisk Insulin Symposium 'Genes ane gene products in the development of diabetes mellitus'. ICS866
EditorsJ. Nerup, T. Mandrup-Poulsen, B. Hokfelt, J. Nerup, T. Mandrup-Poulsen, B. Hokfelt
PublisherElsevier Science Publishers B.V.
Pages249-262
Number of pages14
ISBN (Print)0444813225
StatePublished - Dec 1 1989
EventThe 3rd Nordisk Insulin Symposium 'Genes ane gene products in the development of diabetes mellitus' -
Duration: Jul 3 1989Jul 5 1989

Publication series

NameGenes and gene products in the development of diabetes mellitus: proceedings of the 3rd Nordisk Insulin Symposium 'Genes ane gene products in the development of diabetes mellitus'. ICS866

Conference

ConferenceThe 3rd Nordisk Insulin Symposium 'Genes ane gene products in the development of diabetes mellitus'
Period07/3/8907/5/89

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    Permutt, M. A., McGill, J., Elbein, S. C., Province, M., & Bogardus, C. (1989). Insulin receptor gene polymorphisms (RFLPs) in American Blacks and Pima Indians: an assessment of the use of RFLPs in evaluating a candidate locus for NIDDM. In J. Nerup, T. Mandrup-Poulsen, B. Hokfelt, J. Nerup, T. Mandrup-Poulsen, & B. Hokfelt (Eds.), Genes and gene products in the development of diabetes mellitus: proceedings of the 3rd Nordisk Insulin Symposium 'Genes ane gene products in the development of diabetes mellitus'. ICS866 (pp. 249-262). (Genes and gene products in the development of diabetes mellitus: proceedings of the 3rd Nordisk Insulin Symposium 'Genes ane gene products in the development of diabetes mellitus'. ICS866). Elsevier Science Publishers B.V..