TY - JOUR
T1 - Insulin-like growth factor-I and C-reactive protein during pregnancy and maternal risk of non-epithelial ovarian cancer
T2 - A nested case-control study
AU - Toriola, Adetunji T.
AU - Surcel, Helja Marja
AU - Lundin, Eva
AU - Schock, Helena
AU - Grankvist, Kjell
AU - Pukkala, Eero
AU - Chen, Tianhui
AU - Toniolo, Paolo
AU - Lehtinen, Matti
AU - Zeleniuch-Jacquotte, Anne
AU - Lukanova, Annekatrin
N1 - Funding Information:
The study was approved by the ethical committees of the National Institute for Health and Welfare, Finland, and the German Cancer Research Center, Heidelberg, Germany.
Funding Information:
Acknowledgments This research was supported by the National Cancer Institute at the National Institutes of Health. The funding source had no role in the study design, interpretation of data, and publication of results. This study was conducted while Adetunji T Toriola was at the National Institute for Health and Welfare, Finland. He was supported by a European Association for Cancer Research (EACR) Travel Fellowship Award to visit the Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg. The authors are indebted to Yelena Afanasyeva, Pirjo Kontiokari, Annika Uimonen, and Sara Kuusiniemi for their excellent technical assistance in the conduct of the study.
PY - 2011/11
Y1 - 2011/11
N2 - Background Insulin-like growth factor-I (IGF-I) and C-reactive protein (CRP) may be positively associated with the risk of epithelial ovarian cancer (EOC) but no previous studies have investigated their associations with non-epithelial ovarian cancers (NEOC). Methods A case-control study was nested within the Finnish Maternity Cohort. Case subjects were 58 women diagnosed with sex cord-stromal tumors (SCST) and 30 with germ cell tumors (GCT) after recruitment. Control subjects (144 for SCST and 74 for GCT) were matched for age, parity, and date of blood donation of the index case. Results Doubling of IGF-I concentration was not related to maternal risk of either SCST (OR 0.97, 95% CI 0.58-1.62) or GCT (OR 1.13, 95% CI 0.51-2.51). Similarly, doubling of CRP concentrations was not related to maternal risk of either SCST (OR 1.10, 95% CI 0.85-1.43) or GCT (OR 0.93, 95% CI 0.68-1.28). Conclusions Pre-diagnostic IGF-I and CRP concentrations during the first trimester of pregnancy were not associated with increased risk of NEOC in the mother. Risk factors for NEOC may differ from those of EOC.
AB - Background Insulin-like growth factor-I (IGF-I) and C-reactive protein (CRP) may be positively associated with the risk of epithelial ovarian cancer (EOC) but no previous studies have investigated their associations with non-epithelial ovarian cancers (NEOC). Methods A case-control study was nested within the Finnish Maternity Cohort. Case subjects were 58 women diagnosed with sex cord-stromal tumors (SCST) and 30 with germ cell tumors (GCT) after recruitment. Control subjects (144 for SCST and 74 for GCT) were matched for age, parity, and date of blood donation of the index case. Results Doubling of IGF-I concentration was not related to maternal risk of either SCST (OR 0.97, 95% CI 0.58-1.62) or GCT (OR 1.13, 95% CI 0.51-2.51). Similarly, doubling of CRP concentrations was not related to maternal risk of either SCST (OR 1.10, 95% CI 0.85-1.43) or GCT (OR 0.93, 95% CI 0.68-1.28). Conclusions Pre-diagnostic IGF-I and CRP concentrations during the first trimester of pregnancy were not associated with increased risk of NEOC in the mother. Risk factors for NEOC may differ from those of EOC.
KW - C-reactive protein (CRP)
KW - Insulin-like growth factor (IGF-I)
KW - Nested case-control study
KW - Non-epithelial ovarian cancer
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=82955195834&partnerID=8YFLogxK
U2 - 10.1007/s10552-011-9828-2
DO - 10.1007/s10552-011-9828-2
M3 - Article
C2 - 21833488
AN - SCOPUS:82955195834
SN - 0957-5243
VL - 22
SP - 1607
EP - 1611
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 11
ER -