Insulin increases expression of apobec-1, the catalytic subunit of the apolipoprotein B mRNA editing complex in rat hepatocytes

Mathew A. Von Wronski, Ken Ichi Hirano, Lauren M. Cagen, Henry G. Wilcox, Rajendra Raghow, Fayanne E. Thorngate, Murray Heimberg, Nicholas O. Davidson, Marshall B. Elam

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

We have previously shown that chronic insulin treatment of rat hepatocytes increases the fraction of edited apolipoprotein B (apoB) mRNA from approximately 50% to as much as 90%. We have now examined the effect of insulin on apobec-1 mRNA abundance and demonstrate that increased editing of apoB mRNA following insulin treatment is accompanied by elevated apobec-1 mRNA levels in primary rat hepatocytes. Time-course measurements of the effects of insulin on apoB mRNA editing and apobec-1 mRNA abundance showed that both were elevated almost maximally within 48 hours and sustained for at least 5 days of insulin treatment.

Original languageEnglish
Pages (from-to)869-873
Number of pages5
JournalMetabolism: clinical and experimental
Volume47
Issue number7
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

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