Insulin Clearance in Obesity and Type 2 Diabetes

Han Chow E. Koh, Chao Cao, Bettina Mittendorfer

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Plasma insulin clearance is an important determinant of plasma insulin concentration. In this review, we provide an overview of the factors that regulate insulin removal from plasma and discuss the interrelationships among plasma insulin clearance, excess adiposity, insulin sensitivity, and type 2 diabetes (T2D).We conclude with the perspective that the commonly observed lower insulin clearance rate in people with obesity, compared with lean people, is not a compensatory response to insulin resistance but occurs because insulin sensitivity and insulin clearance are mechanistically, directly linked. Furthermore, insulin clearance decreases postprandially because of the marked increase in insulin delivery to tissues that clear insulin. The commonly observed high postprandial insulin clearance in people with obesity and T2D likely results from the relatively low insulin secretion rate, not an impaired adaptation of tissues that clear insulin.

Original languageEnglish
Article number596
JournalInternational journal of molecular sciences
Volume23
Issue number2
DOIs
StatePublished - Jan 1 2022

Keywords

  • Insulin clearance
  • Insulin extraction
  • Insulin secretion

Fingerprint

Dive into the research topics of 'Insulin Clearance in Obesity and Type 2 Diabetes'. Together they form a unique fingerprint.

Cite this