Instrumentation for load and displacement controlled studies on soft connective tissues

F. Guilak; B. A. Best; A. Ratcliffe; V. C. Mow

Instrumentation for load and displacement controlled studies on soft connective tissues

F. Guilak, B. A. Best, A. Ratcliffe, V. C. Mow

Research output: Contribution to journal › Conference article › peer-review

Abstract

The load bearing function of the intervertebral disc strongly depends on water-proteoglycan-collagen interactions within the disc tissues. In the annulus fibrosus (AF) the relative proportion of the major biochemical constituents - water, collagen and proteoglycan - varies significantly with disc region, radial location and level, and changes with disc herniation and degeneration. However, it is not known what effect these variations in tissue composition have on the mechanical behavior of intervertebral disc tissue. The aims of this study were to develop instrumentation and methodologies to: 1) measure the kinetics of isometric swelling and isometric swelling pressure of precisely prepared cylindrical specimens of soft tissues, such as AF, and 2) determine the intrinsic compressive stiffness and permeability of the AF specimens from specific regions and radial locations.

Original language	English
Pages (from-to)	113-116
Number of pages	4
Journal	American Society of Mechanical Engineers, Applied Mechanics Division, AMD
Volume	98
State	Published - Dec 1 1989
Event	Biomechanics Symposium - 1989 - San Diego, CA, USA Duration: Jul 9 1989 → Jul 12 1989

Cite this

@article{a639a817b25447b48478e94ba3d5adf1,

title = "Instrumentation for load and displacement controlled studies on soft connective tissues",

abstract = "The load bearing function of the intervertebral disc strongly depends on water-proteoglycan-collagen interactions within the disc tissues. In the annulus fibrosus (AF) the relative proportion of the major biochemical constituents - water, collagen and proteoglycan - varies significantly with disc region, radial location and level, and changes with disc herniation and degeneration. However, it is not known what effect these variations in tissue composition have on the mechanical behavior of intervertebral disc tissue. The aims of this study were to develop instrumentation and methodologies to: 1) measure the kinetics of isometric swelling and isometric swelling pressure of precisely prepared cylindrical specimens of soft tissues, such as AF, and 2) determine the intrinsic compressive stiffness and permeability of the AF specimens from specific regions and radial locations.",

author = "F. Guilak and Best, {B. A.} and A. Ratcliffe and Mow, {V. C.}",

year = "1989",

month = dec,

day = "1",

language = "English",

volume = "98",

pages = "113--116",

journal = "American Society of Mechanical Engineers, Applied Mechanics Division, AMD",

issn = "0160-8835",

note = "Biomechanics Symposium - 1989 ; Conference date: 09-07-1989 Through 12-07-1989",

}

TY - JOUR

T1 - Instrumentation for load and displacement controlled studies on soft connective tissues

AU - Guilak, F.

AU - Best, B. A.

AU - Ratcliffe, A.

AU - Mow, V. C.

PY - 1989/12/1

Y1 - 1989/12/1

N2 - The load bearing function of the intervertebral disc strongly depends on water-proteoglycan-collagen interactions within the disc tissues. In the annulus fibrosus (AF) the relative proportion of the major biochemical constituents - water, collagen and proteoglycan - varies significantly with disc region, radial location and level, and changes with disc herniation and degeneration. However, it is not known what effect these variations in tissue composition have on the mechanical behavior of intervertebral disc tissue. The aims of this study were to develop instrumentation and methodologies to: 1) measure the kinetics of isometric swelling and isometric swelling pressure of precisely prepared cylindrical specimens of soft tissues, such as AF, and 2) determine the intrinsic compressive stiffness and permeability of the AF specimens from specific regions and radial locations.

AB - The load bearing function of the intervertebral disc strongly depends on water-proteoglycan-collagen interactions within the disc tissues. In the annulus fibrosus (AF) the relative proportion of the major biochemical constituents - water, collagen and proteoglycan - varies significantly with disc region, radial location and level, and changes with disc herniation and degeneration. However, it is not known what effect these variations in tissue composition have on the mechanical behavior of intervertebral disc tissue. The aims of this study were to develop instrumentation and methodologies to: 1) measure the kinetics of isometric swelling and isometric swelling pressure of precisely prepared cylindrical specimens of soft tissues, such as AF, and 2) determine the intrinsic compressive stiffness and permeability of the AF specimens from specific regions and radial locations.

UR - http://www.scopus.com/inward/record.url?scp=0024866379&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0024866379

SN - 0160-8835

VL - 98

SP - 113

EP - 116

JO - American Society of Mechanical Engineers, Applied Mechanics Division, AMD

JF - American Society of Mechanical Engineers, Applied Mechanics Division, AMD

T2 - Biomechanics Symposium - 1989

Y2 - 9 July 1989 through 12 July 1989

ER -

Instrumentation for load and displacement controlled studies on soft connective tissues

Abstract

Other files and links

Fingerprint

Cite this