Insights into mechanisms causing the maternal age-induced decrease in oocyte quality

Anna L. Boudoures, Kelle H. Moley

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Female fertility declines with age, but the underlying mechanisms remain unclear. Here, we review the recent literature on the role of reactive oxygen species (ROS) within the oocytes. Specifically, ROS increase with age, damaging mitochondria and proteins important in oocyte maturation and meiosis. The damages to mitochondria impair ATP production. ATP levels in oocytes have been linked to successful completion of meiosis prior to ovulation and mediating the appropriate response to sperm binding. ROS also damage proteins important in DNA repair. Meiosis-specific homologs of DNA repair proteins have a critical role in recombination and preventing aneuploidy. Therefore, ROS-induced mitochondrial damage has widespread impacts on multiple aspects of oocyte quality. Some treatments are discussed which have shown to be effective in decreasing ROS-induced damage and lowering aneuploidy, providing hope to older women attempting to conceive. However, gaps in knowledge remain and require further investigation before more targeted treatments can be developed.

Original languageEnglish
Title of host publicationBiennial Review of Infertility
PublisherSpringer International Publishing
Pages43-55
Number of pages13
Volume4
ISBN (Electronic)9783319178493
ISBN (Print)9783319178486
DOIs
StatePublished - Jan 1 2015

Keywords

  • Advanced maternal age
  • Antioxidant therapy
  • DNA
  • Damage
  • Meiosis
  • Oocyte quality
  • Reactive oxygen species (ROS)

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    Boudoures, A. L., & Moley, K. H. (2015). Insights into mechanisms causing the maternal age-induced decrease in oocyte quality. In Biennial Review of Infertility (Vol. 4, pp. 43-55). Springer International Publishing. https://doi.org/10.1007/978-3-319-17849-3_4