Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism

Randal J. Kaufman; Siyan Cao

doi:10.1002/emmm.201000076

Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism

Randal J. Kaufman, Siyan Cao

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Inositol-requiring 1 (IRE1)/X-box-binding protein 1 (XBP1)-mediated signalling represents the most conserved branch of the unfolded protein response. A series of recent studies reveal novel and potentially ancient roles for this pathway in the coordination of metabolic and immune responses.

Original language	English
Pages (from-to)	189-192
Number of pages	4
Journal	EMBO Molecular Medicine
Volume	2
Issue number	6
DOIs	https://doi.org/10.1002/emmm.201000076
State	Published - Jun 2010

Keywords

Inflammation
Insulin
Phosphoinositide 3-kinase (PI3K)
Toll-like receptors (TLR)
Unfolded protein response (UPR)

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10.1002/emmm.201000076

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abstract = "Inositol-requiring 1 (IRE1)/X-box-binding protein 1 (XBP1)-mediated signalling represents the most conserved branch of the unfolded protein response. A series of recent studies reveal novel and potentially ancient roles for this pathway in the coordination of metabolic and immune responses.",

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KW - Phosphoinositide 3-kinase (PI3K)

KW - Toll-like receptors (TLR)

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Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism

Abstract

Keywords

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