Innate or adaptive immunity? The example of natural killer cells

Eric Vivier, David H. Raulet, Alessandro Moretta, Michael A. Caligiuri, Laurence Zitvogel, Lewis L. Lanier, Wayne M. Yokoyama, Sophie Ugolini

Research output: Contribution to journalReview articlepeer-review

2052 Scopus citations

Abstract

Natural killer (NK) cells were originally defined as effector lymphocytes of innate immunity endowed with constitutive cytolytic functions. More recently, a more nuanced view of NK cells has emerged. NK cells are now recognized to express a repertoire of activating and inhibitory receptors that is calibrated to ensure self-tolerance while allowing efficacy against assaults such as viral infection and tumor development. Moreover, NK cells do not react in an invariant manner but rather adapt to their environment. Finally, recent studies have unveiled that NK cells can also mount a form of antigen-specific immunologic memory. NK cells thus exert sophisticated biological functions that are attributes of both innate and adaptive immunity, blurring the functional borders between these two arms of the immune response.

Original languageEnglish
Pages (from-to)44-49
Number of pages6
JournalScience
Volume331
Issue number6013
DOIs
StatePublished - Jan 7 2011

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