Innate Neural Stem Cell Heterogeneity Determines the Patterning of Glioma Formation in Children

Da Yong Lee, Scott M. Gianino, David H. Gutmann

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

The concept that gliomas comprise a heterogeneous group of diseases distinguished by their developmental origin raises the intriguing possibility that neural stem cells (NSCs) from different germinal zones have differential capacities to respond to glioma-causing genetic changes. We demonstrate that lateral ventricle subventricular zone NSCs are molecularly and functionally distinct from those of the third ventricle. Consistent with a unique origin for pediatric low-grade glioma, third ventricle, but not lateral ventricle, NSCs hyperproliferate in response to mutations characteristic of childhood glioma. Finally, we demonstrate that pediatric optic gliomas in Nf1 genetically engineered mice arise from the third ventricle. Collectively, these observations establish the importance of innate brain region NSC heterogeneity in the patterning of gliomagenesis in children and adults.

Original languageEnglish
Pages (from-to)131-138
Number of pages8
JournalCancer Cell
Volume22
Issue number1
DOIs
StatePublished - Jul 10 2012

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