Innate lymphoid cells in mucosal immunity

Santosh K. Panda, Marco Colonna

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Innate lymphoid cells (ILCs) are innate counterparts of T cells that contribute to immune responses by secreting effector cytokines and regulating the functions of other innate and adaptive immune cells. ILCs carry out some unique functions but share some tasks with T cells. ILCs are present in lymphoid and non-lymphoid organs and are particularly abundant at the mucosal barriers, where they are exposed to allergens, commensal microbes, and pathogens. The impact of ILCs in mucosal immune responses has been extensively investigated in the gastrointestinal and respiratory tracts, as well as in the oral cavity. Here we review the state-of-the-art knowledge of ILC functions in infections, allergy and autoimmune disorders of the mucosal barriers.

Original languageEnglish
Article number861
JournalFrontiers in immunology
Volume10
Issue numberMAY
DOIs
StatePublished - 2019

Keywords

  • Allergy
  • Asthma
  • COPD
  • IBD
  • ILCs
  • Inflammatory bowel diseases
  • Mucosal infections
  • NK cells

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