TY - JOUR
T1 - Innate Lymphoid Cells
T2 - Diversity, Plasticity, and Unique Functions in Immunity
AU - Colonna, Marco
N1 - Funding Information:
Marco Colonna is recipient of research support from Pfizer.
Funding Information:
I would like to thank Jennifer Bando, Marina Cella, Victor Cortez, Susan Gilfillan, Gene Oltz, Santosh Panda, and Michelle Robinette for helpful suggestions. This work is supported by the US National Institutes of Health (UO1 AI095542, RO1 DE025884, R01 AI134236, and RO1 DK103039) and Pfizer.
Publisher Copyright:
© 2018
PY - 2018/6/19
Y1 - 2018/6/19
N2 - Type 1, 2, and 3 innate lymphoid cells (ILCs) have emerged as tissue-resident innate correlates of T helper 1 (Th1), Th2, and Th17 cells. Recent studies suggest that ILCs are more diverse than originally proposed; this might reflect truly distinct lineages or adaptation of ILCs to disparate tissue microenvironments, known as plasticity. Given that ILCs strikingly resemble T cells, are they redundant? While the regulation, timing, and magnitude of ILC and primary T cell responses differ, tissue-resident memory T cells may render ILCs redundant during secondary responses. The unique impact of ILCs in immunity is probably embodied in the extensive array of surface and intracellular receptors that endow these cells with the ability to distinguish between normal and pathogenic components, interact with other cells, and calibrate their cytokine secretion accordingly. Here I review recent advances in elucidating the diversity of ILCs and discuss their unique and redundant functions. Innate lymphoid cells (ILCs) are tissue-resident correlates of T helper 1 (Th1), Th2, and Th17 cells. Colonna reviews recent advances in understanding ILC diversity and functional plasticity—their unique and redundant functions, receptor repertoires, and regulation of gene-expression programs.
AB - Type 1, 2, and 3 innate lymphoid cells (ILCs) have emerged as tissue-resident innate correlates of T helper 1 (Th1), Th2, and Th17 cells. Recent studies suggest that ILCs are more diverse than originally proposed; this might reflect truly distinct lineages or adaptation of ILCs to disparate tissue microenvironments, known as plasticity. Given that ILCs strikingly resemble T cells, are they redundant? While the regulation, timing, and magnitude of ILC and primary T cell responses differ, tissue-resident memory T cells may render ILCs redundant during secondary responses. The unique impact of ILCs in immunity is probably embodied in the extensive array of surface and intracellular receptors that endow these cells with the ability to distinguish between normal and pathogenic components, interact with other cells, and calibrate their cytokine secretion accordingly. Here I review recent advances in elucidating the diversity of ILCs and discuss their unique and redundant functions. Innate lymphoid cells (ILCs) are tissue-resident correlates of T helper 1 (Th1), Th2, and Th17 cells. Colonna reviews recent advances in understanding ILC diversity and functional plasticity—their unique and redundant functions, receptor repertoires, and regulation of gene-expression programs.
UR - http://www.scopus.com/inward/record.url?scp=85048628201&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2018.05.013
DO - 10.1016/j.immuni.2018.05.013
M3 - Review article
C2 - 29924976
AN - SCOPUS:85048628201
SN - 1074-7613
VL - 48
SP - 1104
EP - 1117
JO - Immunity
JF - Immunity
IS - 6
ER -