Abstract
Innate lymphoid cells (ILCs) are a new class of immune cells that include natural killer (NK) cells and appear to be the innate counterparts to CD4+ helper T cells and CD8+ cytotoxic T cells based on developmental and functional similarities. Like T cells, both NK cells and other ILCs also show connections to the major histocompatibility complex (MHC). In human and mouse, NK cells recognize and respond to classical and nonclassical MHC I molecules as well as structural homologues, whereas mouse ILCs have recently been shown to express MHC II. We describe the history of MHC I recognition by NK cells and discuss emerging roles for MHC II expression by ILC subsets, making comparisons between both mouse and human when possible.
Original language | English |
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Pages (from-to) | 5-11 |
Number of pages | 7 |
Journal | HLA |
Volume | 87 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2016 |
Keywords
- Cytokines
- Human
- Human leukocyte antigen
- Innate
- Innate lymphoid cells
- MHC
- Mouse