TY - JOUR
T1 - Innate Lymphoid Cells
T2 - 10 Years On
AU - Vivier, Eric
AU - Artis, David
AU - Colonna, Marco
AU - Diefenbach, Andreas
AU - Di Santo, James P.
AU - Eberl, Gérard
AU - Koyasu, Shigeo
AU - Locksley, Richard M.
AU - McKenzie, Andrew N.J.
AU - Mebius, Reina E.
AU - Powrie, Fiona
AU - Spits, Hergen
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/8/23
Y1 - 2018/8/23
N2 - Innate lymphoid cells (ILCs) are lymphocytes that do not express the type of diversified antigen receptors expressed on T cells and B cells. ILCs are largely tissue-resident cells and are deeply integrated into the fabric of tissues. The discovery and investigation of ILCs over the past decade has changed our perception of immune regulation and how the immune system contributes to the maintenance of tissue homeostasis. We now know that cytokine-producing ILCs contribute to multiple immune pathways by, for example, sustaining appropriate immune responses to commensals and pathogens at mucosal barriers, potentiating adaptive immunity, and regulating tissue inflammation. Critically, the biology of ILCs also extends beyond classical immunology to metabolic homeostasis, tissue remodeling, and dialog with the nervous system. The last 10 years have also contributed to our greater understanding of the transcriptional networks that regulate lymphocyte commitment and delineation. This, in conjunction with the recent advances in our understanding of the influence of local tissue microenvironments on the plasticity and function of ILCs, has led to a re-evaluation of their existing categorization. In this review, we distill the advances in ILC biology over the past decade to refine the nomenclature of ILCs and highlight the importance of ILCs in tissue homeostasis, morphogenesis, metabolism, repair, and regeneration. Since the discovery of innate lymphoid cells a decade ago, studies in this field have drastically expanded our understanding of the role of the immune system in the maintenance of homeostasis. This Review explores the immune functions of these cells and their connection to metabolism, tissue repair, and the nervous system.
AB - Innate lymphoid cells (ILCs) are lymphocytes that do not express the type of diversified antigen receptors expressed on T cells and B cells. ILCs are largely tissue-resident cells and are deeply integrated into the fabric of tissues. The discovery and investigation of ILCs over the past decade has changed our perception of immune regulation and how the immune system contributes to the maintenance of tissue homeostasis. We now know that cytokine-producing ILCs contribute to multiple immune pathways by, for example, sustaining appropriate immune responses to commensals and pathogens at mucosal barriers, potentiating adaptive immunity, and regulating tissue inflammation. Critically, the biology of ILCs also extends beyond classical immunology to metabolic homeostasis, tissue remodeling, and dialog with the nervous system. The last 10 years have also contributed to our greater understanding of the transcriptional networks that regulate lymphocyte commitment and delineation. This, in conjunction with the recent advances in our understanding of the influence of local tissue microenvironments on the plasticity and function of ILCs, has led to a re-evaluation of their existing categorization. In this review, we distill the advances in ILC biology over the past decade to refine the nomenclature of ILCs and highlight the importance of ILCs in tissue homeostasis, morphogenesis, metabolism, repair, and regeneration. Since the discovery of innate lymphoid cells a decade ago, studies in this field have drastically expanded our understanding of the role of the immune system in the maintenance of homeostasis. This Review explores the immune functions of these cells and their connection to metabolism, tissue repair, and the nervous system.
KW - immunity
KW - innate lymphoid cells
KW - metabolism
KW - neuro-immunology
KW - plasticity
KW - tissue remodeling
UR - http://www.scopus.com/inward/record.url?scp=85050861774&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2018.07.017
DO - 10.1016/j.cell.2018.07.017
M3 - Review article
C2 - 30142344
AN - SCOPUS:85050861774
SN - 0092-8674
VL - 174
SP - 1054
EP - 1066
JO - Cell
JF - Cell
IS - 5
ER -