Innate lymphoid cell function in the context of adaptive immunity

Jennifer K. Bando, Marco Colonna

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

Innate lymphoid cells (ILCs) are a family of innate immune cells that have diverse functions during homeostasis and disease. Subsets of ILCs have phenotypes that mirror those of polarized helper T cell subsets in their expression of core transcription factors and effector cytokines. Given the similarities between these two classes of lymphocytes, it is important to understand which functions of ILCs are specialized and which are redundant with those of T cells. Here we discuss genetic mouse models that have been used to delineate the contributions of ILCs versus those of T cells and review the current understanding of the specialized in vivo functions of ILCs.

Original languageEnglish
Pages (from-to)783-789
Number of pages7
JournalNature immunology
Volume17
Issue number7
DOIs
StatePublished - Jun 21 2016

Fingerprint Dive into the research topics of 'Innate lymphoid cell function in the context of adaptive immunity'. Together they form a unique fingerprint.

  • Cite this