TY - JOUR
T1 - Innate immunity
T2 - the first line of defense against SARS-CoV-2
AU - Diamond, Michael S.
AU - Kanneganti, Thirumala Devi
N1 - Funding Information:
We apologize to our colleagues in the field whose work could not be cited due to space limitations. We thank members of the Kanneganti laboratory for their comments and suggestions. Additionally, we thank M. Zheng for scientific discussions and suggestions. Work from the Kanneganti laboratory is supported by the US National Institutes of Health (AI101935, AI124346, AI160179, AR056296 and CA253095 to T.-D.K.) and the American Lebanese Syrian Associated Charities (to T.-D.K.). Work on SARS-CoV-2 in the Diamond laboratory is supported by AI157155 and NIAID Centers of Excellence for Influenza Research and Response contract 75N93021C00014.
Publisher Copyright:
© 2022, Springer Nature America, Inc.
PY - 2022/2
Y1 - 2022/2
N2 - The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity and mortality. While most infections are mild, some patients experience severe and potentially fatal systemic inflammation, tissue damage, cytokine storm and acute respiratory distress syndrome. The innate immune system acts as the first line of defense, sensing the virus through pattern recognition receptors and activating inflammatory pathways that promote viral clearance. Here, we discuss innate immune processes involved in SARS-CoV-2 recognition and the resultant inflammation. Improved understanding of how the innate immune system detects and responds to SARS-CoV-2 will help identify targeted therapeutic modalities that mitigate severe disease and improve patient outcomes.
AB - The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity and mortality. While most infections are mild, some patients experience severe and potentially fatal systemic inflammation, tissue damage, cytokine storm and acute respiratory distress syndrome. The innate immune system acts as the first line of defense, sensing the virus through pattern recognition receptors and activating inflammatory pathways that promote viral clearance. Here, we discuss innate immune processes involved in SARS-CoV-2 recognition and the resultant inflammation. Improved understanding of how the innate immune system detects and responds to SARS-CoV-2 will help identify targeted therapeutic modalities that mitigate severe disease and improve patient outcomes.
UR - http://www.scopus.com/inward/record.url?scp=85123972991&partnerID=8YFLogxK
U2 - 10.1038/s41590-021-01091-0
DO - 10.1038/s41590-021-01091-0
M3 - Review article
C2 - 35105981
AN - SCOPUS:85123972991
VL - 23
SP - 165
EP - 176
JO - Nature Immunology
JF - Nature Immunology
SN - 1529-2908
IS - 2
ER -