Innate immunity in lung transplantation

Hailey M. Shepherd, Jason M. Gauthier, Wenjun Li, Alexander S. Krupnick, Andrew E. Gelman, Daniel Kreisel

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Innate immune pathways early after pulmonary transplantation have been shown to cause primary graft dysfunction (PGD) and also predispose to late graft failure. Recent studies in animal models have elucidated critical mechanisms governing such innate immune responses. Here, we discuss pathways of inflammatory cell death, triggers for sterile and infectious inflammation, and signaling cascades that mediate lung injury early after transplantation. These studies highlight potential avenues for lung-specific therapies early following lung transplantation to dampen innate immune responses and improve outcomes.

Original languageEnglish
Pages (from-to)562-568
Number of pages7
JournalJournal of Heart and Lung Transplantation
Volume40
Issue number7
DOIs
StatePublished - Jul 2021

Keywords

  • cell death
  • damage-associated molecular patterns
  • graft rejection
  • innate immunity
  • lung transplantation

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