Innate immune interactions within the central nervous system modulate pathogenesis of viral infections

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

The innate immune system mediates protection against neurotropic viruses that replicate in the central nervous system (CNS). Virus infection within specific cells of the CNS triggers activation of several families of pattern recognition receptors including Toll-like receptors, retinoic acid-inducible gene I like receptors, nucleotide-binding oligomerization domain-like receptors, and cytosolic DNA sensors. In this review, we highlight recent advances in our understanding of how cell-intrinsic host defenses within the CNS modulate infection of different DNA and RNA viruses.

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalCurrent Opinion in Immunology
Volume36
DOIs
StatePublished - Oct 1 2015

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