Innate immune escape by Dengue and West Nile viruses

Michaela U. Gack, Michael S. Diamond

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Dengue (DENV) and West Nile (WNV) viruses are mosquito-transmitted flaviviruses that cause significant morbidity and mortality worldwide. Disease severity and pathogenesis of DENV and WNV infections in humans depend on many factors, including pre-existing immunity, strain virulence, host genetics and virus–host interactions. Among the flavivirus-host interactions, viral evasion of type I interferon (IFN)-mediated innate immunity has a critical role in modulating pathogenesis. DENV and WNV have evolved effective strategies to evade immune surveillance pathways that lead to IFN induction and to block signaling downstream of the IFN-α/β receptor. Here, we discuss recent advances in our understanding of the molecular mechanisms by which DENV and WNV antagonize the type I IFN response in human cells.

Original languageEnglish
Pages (from-to)119-128
Number of pages10
JournalCurrent Opinion in Virology
Volume20
DOIs
StatePublished - Oct 1 2016

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