TY - JOUR
T1 - Innate immune escape by Dengue and West Nile viruses
AU - Gack, Michaela U.
AU - Diamond, Michael S.
N1 - Funding Information:
We apologize to all colleagues whose important contributions could not be cited due to space constraints. Current research in the Gack laboratory is supported by National Institutes of Health (NIH) grants (R01 AI087846 and R21 AI118509) and an award from the PML Consortium. Research in the Diamond laboratory is supported by NIH grants (U19 AI083019, U19 AI106772, R01 AI104972, and R01 AI104002).
Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Dengue (DENV) and West Nile (WNV) viruses are mosquito-transmitted flaviviruses that cause significant morbidity and mortality worldwide. Disease severity and pathogenesis of DENV and WNV infections in humans depend on many factors, including pre-existing immunity, strain virulence, host genetics and virus–host interactions. Among the flavivirus-host interactions, viral evasion of type I interferon (IFN)-mediated innate immunity has a critical role in modulating pathogenesis. DENV and WNV have evolved effective strategies to evade immune surveillance pathways that lead to IFN induction and to block signaling downstream of the IFN-α/β receptor. Here, we discuss recent advances in our understanding of the molecular mechanisms by which DENV and WNV antagonize the type I IFN response in human cells.
AB - Dengue (DENV) and West Nile (WNV) viruses are mosquito-transmitted flaviviruses that cause significant morbidity and mortality worldwide. Disease severity and pathogenesis of DENV and WNV infections in humans depend on many factors, including pre-existing immunity, strain virulence, host genetics and virus–host interactions. Among the flavivirus-host interactions, viral evasion of type I interferon (IFN)-mediated innate immunity has a critical role in modulating pathogenesis. DENV and WNV have evolved effective strategies to evade immune surveillance pathways that lead to IFN induction and to block signaling downstream of the IFN-α/β receptor. Here, we discuss recent advances in our understanding of the molecular mechanisms by which DENV and WNV antagonize the type I IFN response in human cells.
UR - http://www.scopus.com/inward/record.url?scp=84992512259&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2016.09.013
DO - 10.1016/j.coviro.2016.09.013
M3 - Review article
C2 - 27792906
AN - SCOPUS:84992512259
SN - 1879-6257
VL - 20
SP - 119
EP - 128
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -