Innate immune control and regulation of influenza virus infections

Jodi McGill, Jonathan W. Heusel, Kevin L. Legge

Research output: Contribution to journalReview articlepeer-review

119 Scopus citations

Abstract

Adaptive immune responses are critical for the control and clearance of influenza A virus (IAV) infection. However, in recent years, it has become increasingly apparent that innate immune cells, including natural killer cells, alveolar macrophages (aMφ), and dendritic cells (DC) are essential following IAV infection in the direct control of viral replication or in the induction and regulation of virus-specific adaptive immune responses. This review will discuss the role of these innate immune cells following IAV infection, with a particular focus on DC and their ability to induce and regulate the adaptive IAV-specific immune response.

Original languageEnglish
Pages (from-to)803-812
Number of pages10
JournalJournal of Leukocyte Biology
Volume86
Issue number4
DOIs
StatePublished - Oct 2009

Keywords

  • Dendritic cells
  • Macrophages
  • NK cells

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