TY - JOUR
T1 - Initial study of an asymmetric PET system dedicated to breast cancer imaging
AU - Tai, Yuan Chuan
AU - Wu, Heyu
AU - Janecek, Martin
N1 - Funding Information:
Manuscript received November 12, 2004, revised September 20, 2005. This work was supported in part by the National Cancer Institute of NIH under Grant CA-110011. The authors are with Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO 63110 USA (e-mail: [email protected]). Digital Object Identifier 10.1109/TNS.2006.869853
PY - 2006/2
Y1 - 2006/2
N2 - We are developing a positron emission tomography (PET) system dedicated to breast cancer imaging and based on a pseudo-pinhole PET geometry. The system consists of a small half-ring (r = 153 mm) of high-resolution LSO detectors and a large half-ring (R = 413 mm) of medium-resolution LSO detectors. The coincidence detection profile between a small LSO crystal and a large LSO crystal reveals that, when the object imaged is located close to the small detector, the image resolution is primarily determined by the intrinsic spatial resolution of the small detector, and is only slightly affected by the resolution of the large detector. The dimensions of the crystals are 1.6 × 1.6 × 20 mm 3 for the small half-ring and 4.3 × 4.3 × 25 mm 3 for the large half-ring. Monte Carlo simulation of the system was performed using a modified SimSET package. The detectors in the small half ring are modeled as 2- or 4-layer detectors with DOI capability. One-mm point sources were simulated to measure the image resolution of the system at 0, 2, 6, and 10 cm offset along the +X, +Y and -Y directions. Results suggest image resolutions of 1.7-2.5 mm FWHM for breast tissues and 1.8-3.1 mm FWHM for tissues near the chest wall, including internal and axillary lymph nodes. Sensitivity of the system ranges from 5.4% to 7.8% and can be significantly increased if two planar detectors are attached to the system along the axial direction.
AB - We are developing a positron emission tomography (PET) system dedicated to breast cancer imaging and based on a pseudo-pinhole PET geometry. The system consists of a small half-ring (r = 153 mm) of high-resolution LSO detectors and a large half-ring (R = 413 mm) of medium-resolution LSO detectors. The coincidence detection profile between a small LSO crystal and a large LSO crystal reveals that, when the object imaged is located close to the small detector, the image resolution is primarily determined by the intrinsic spatial resolution of the small detector, and is only slightly affected by the resolution of the large detector. The dimensions of the crystals are 1.6 × 1.6 × 20 mm 3 for the small half-ring and 4.3 × 4.3 × 25 mm 3 for the large half-ring. Monte Carlo simulation of the system was performed using a modified SimSET package. The detectors in the small half ring are modeled as 2- or 4-layer detectors with DOI capability. One-mm point sources were simulated to measure the image resolution of the system at 0, 2, 6, and 10 cm offset along the +X, +Y and -Y directions. Results suggest image resolutions of 1.7-2.5 mm FWHM for breast tissues and 1.8-3.1 mm FWHM for tissues near the chest wall, including internal and axillary lymph nodes. Sensitivity of the system ranges from 5.4% to 7.8% and can be significantly increased if two planar detectors are attached to the system along the axial direction.
KW - Biomedical nuclear imaging
KW - Imaging
KW - Positron emission tomography (PET)
UR - http://www.scopus.com/inward/record.url?scp=33645699260&partnerID=8YFLogxK
U2 - 10.1109/TNS.2006.869853
DO - 10.1109/TNS.2006.869853
M3 - Article
AN - SCOPUS:33645699260
SN - 0018-9499
VL - 53
SP - 121
EP - 126
JO - IEEE Transactions on Nuclear Science
JF - IEEE Transactions on Nuclear Science
IS - 1
ER -