Initial studies of in vivo absorbing and scattering heterogeneity in near-infrared tomographic breast imaging

Troy O. McBride, Brian W. Pogue, Shudong Jiang, Ulf L. Österberg, Keith D. Paulsen, Steven P. Poplack

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

Simultaneously recovered absorption and scattering images that separate these optical property features within the female breast are demonstrated from frequency-domain measurements. A study of known absorbing and scattering objects is presented as a foundation for interpreting these in vivo images once the contrast space has been fully characterized. No measurable influence of absorbing-object contrast appears in the scattering images, whereas localized scattering contrast enhances the corresponding region within the absorption image by approximately 30% (e.g., a 2:1 scatterer also reconstructs as an ≈1.3:l absorber). Scattering and absorption images of a female volunteer with a 3.4-cm fibroadenoma show a clear 2:1 localized increase in absorption coefficient with little or no evidence of scattering enhancement in the lesion.

Original languageEnglish
Pages (from-to)822-824
Number of pages3
JournalOptics Letters
Volume26
Issue number11
DOIs
StatePublished - Jun 1 2001
Externally publishedYes

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