TY - JOUR
T1 - Initial clinical experience with helical tomotherapy for head and neck cancer
AU - Chen, Allen M.
AU - Jennelle, Richard L.S.
AU - Sreeraman, Radhika
AU - Yang, Claus C.
AU - Liu, Tianxiao
AU - Vijayakumar, Srinivasan
AU - Purdy, James A.
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Background. To report a single-institutional experience with the use of helical tomotherapy (HT)-based intensity-modulated radiotherapy (IMRT) for head and neck cancer. Methods. Seventy-seven consecutive patients were treated with HT for squamous cell carcinoma of the head and neck to a median dose of 66 Gy (range, 60 to 72 Gy). Megavoltage CT scans were obtained as part of an image-guided registration protocol for patient alignment before each treatment. Concurrent chemotherapy was administered to 48 patients (62%). Results. The 2-year estimates of overall survival, localregional control, and disease-free survival were 82%, 77%, and 71%, respectively. Spatial evaluation of local-regional failures revealed that 16 of the 18 patients who progressed in the primary site or neck failed in the high-dose planning target volume (PTV). Conclusions. HT appears to achieve clinical outcomes comparable to contemporary series reporting on IMRT for head and neck cancer.
AB - Background. To report a single-institutional experience with the use of helical tomotherapy (HT)-based intensity-modulated radiotherapy (IMRT) for head and neck cancer. Methods. Seventy-seven consecutive patients were treated with HT for squamous cell carcinoma of the head and neck to a median dose of 66 Gy (range, 60 to 72 Gy). Megavoltage CT scans were obtained as part of an image-guided registration protocol for patient alignment before each treatment. Concurrent chemotherapy was administered to 48 patients (62%). Results. The 2-year estimates of overall survival, localregional control, and disease-free survival were 82%, 77%, and 71%, respectively. Spatial evaluation of local-regional failures revealed that 16 of the 18 patients who progressed in the primary site or neck failed in the high-dose planning target volume (PTV). Conclusions. HT appears to achieve clinical outcomes comparable to contemporary series reporting on IMRT for head and neck cancer.
KW - Head and neck cancer
KW - Helical tomotherapy
KW - Intensity-modulated radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=72449203190&partnerID=8YFLogxK
U2 - 10.1002/hed.21123
DO - 10.1002/hed.21123
M3 - Article
C2 - 19405087
AN - SCOPUS:72449203190
VL - 31
SP - 1571
EP - 1578
JO - Head & Neck
JF - Head & Neck
SN - 1043-3074
IS - 12
ER -