Initial Clinical Experience of MR-Guided Radiotherapy for Non-Small Cell Lung Cancer

Cathryn B. Crockett; Pamela Samson; Robert Chuter; Michael Dubec; Corinne Faivre-Finn; Olga L. Green; Sara L. Hackett; Fiona McDonald; Clifford Robinson; Anna Maria Shiarli; Michael W. Straza; Joost J.C. Verhoeff; Maria Werner-Wasik; Gregory Vlacich; David Cobben

doi:10.3389/fonc.2021.617681

Initial Clinical Experience of MR-Guided Radiotherapy for Non-Small Cell Lung Cancer

Cathryn B. Crockett, Pamela Samson, Robert Chuter, Michael Dubec, Corinne Faivre-Finn, Olga L. Green, Sara L. Hackett, Fiona McDonald, Clifford Robinson, Anna Maria Shiarli, Michael W. Straza, Joost J.C. Verhoeff, Maria Werner-Wasik, Gregory Vlacich, David Cobben

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Abstract

Curative-intent radiotherapy plays an integral role in the treatment of lung cancer and therefore improving its therapeutic index is vital. MR guided radiotherapy (MRgRT) systems are the latest technological advance which may help with achieving this aim. The majority of MRgRT treatments delivered to date have been stereotactic body radiation therapy (SBRT) based and include the treatment of (ultra-) central tumors. However, there is a move to also implement MRgRT as curative-intent treatment for patients with inoperable locally advanced NSCLC. This paper presents the initial clinical experience of using the two commercially available systems to date: the ViewRay MRIdian and Elekta Unity. The challenges and potential solutions associated with MRgRT in lung cancer will also be highlighted.

Original language	English
Article number	617681
Journal	Frontiers in Oncology
Volume	11
DOIs	https://doi.org/10.3389/fonc.2021.617681
State	Published - Mar 10 2021

Keywords

MR-guided radiotherapy (MRgRT)
adaptive
external beam radiotherapy
image-guided radiotherapy (IGRT)
magnetic resonance imaging (MRI)
non-small cell lung cancer (NSCLC)
stereotactic body radiation therapy (SBRT)

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Crockett, C. B., Samson, P., Chuter, R., Dubec, M., Faivre-Finn, C., Green, O. L., Hackett, S. L., McDonald, F., Robinson, C., Shiarli, A. M., Straza, M. W., Verhoeff, J. J. C., Werner-Wasik, M., Vlacich, G., & Cobben, D. (2021). Initial Clinical Experience of MR-Guided Radiotherapy for Non-Small Cell Lung Cancer. Frontiers in Oncology, 11, Article 617681. https://doi.org/10.3389/fonc.2021.617681

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abstract = "Curative-intent radiotherapy plays an integral role in the treatment of lung cancer and therefore improving its therapeutic index is vital. MR guided radiotherapy (MRgRT) systems are the latest technological advance which may help with achieving this aim. The majority of MRgRT treatments delivered to date have been stereotactic body radiation therapy (SBRT) based and include the treatment of (ultra-) central tumors. However, there is a move to also implement MRgRT as curative-intent treatment for patients with inoperable locally advanced NSCLC. This paper presents the initial clinical experience of using the two commercially available systems to date: the ViewRay MRIdian and Elekta Unity. The challenges and potential solutions associated with MRgRT in lung cancer will also be highlighted.",

keywords = "MR-guided radiotherapy (MRgRT), adaptive, external beam radiotherapy, image-guided radiotherapy (IGRT), magnetic resonance imaging (MRI), non-small cell lung cancer (NSCLC), stereotactic body radiation therapy (SBRT)",

author = "Crockett, {Cathryn B.} and Pamela Samson and Robert Chuter and Michael Dubec and Corinne Faivre-Finn and Green, {Olga L.} and Hackett, {Sara L.} and Fiona McDonald and Clifford Robinson and Shiarli, {Anna Maria} and Straza, {Michael W.} and Verhoeff, {Joost J.C.} and Maria Werner-Wasik and Gregory Vlacich and David Cobben",

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year = "2021",

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AU - Dubec, Michael

AU - Faivre-Finn, Corinne

AU - Green, Olga L.

AU - Hackett, Sara L.

AU - McDonald, Fiona

AU - Robinson, Clifford

AU - Shiarli, Anna Maria

AU - Straza, Michael W.

AU - Verhoeff, Joost J.C.

AU - Werner-Wasik, Maria

AU - Vlacich, Gregory

AU - Cobben, David

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KW - external beam radiotherapy

KW - image-guided radiotherapy (IGRT)

KW - magnetic resonance imaging (MRI)

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Initial Clinical Experience of MR-Guided Radiotherapy for Non-Small Cell Lung Cancer

Abstract

Keywords

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