Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells

Marco Colonna, Hideo Nakajima, Marina Cella

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

We review the structure, cellular distribution, ligand specificity, and function of two emerging types of receptors involved in natural killer (NK) and myeloid cell recognition of other cells: ILT/LIR/MIR and 2B4 receptors. ILT/LIR/MIR receptors are differentially expressed on lymphoid and myeloid cells and two of them, ILT2 and ILT4, recognize HLA class I molecules. Whereas some receptors inhibit, others induce cell activation. 2B4 is broadly expressed on leukocytes, binds CD48, and mediates non-MHC-restricted cytotoxicity by NK cells.

Original languageEnglish
Pages (from-to)718-722
Number of pages5
JournalJournal of Leukocyte Biology
Volume66
Issue number5
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Keywords

  • Basophils
  • CD48
  • Cell sulface molecules
  • Dendritic cells
  • Immunoglobulin superfamily
  • Major histocompatibility complex
  • Monocytes/macrophages

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