TY - JOUR
T1 - Inhibitory and activating receptors involved in immune surveillance by human NK and myeloid cells
AU - Colonna, Marco
AU - Nakajima, Hideo
AU - Cella, Marina
PY - 1999
Y1 - 1999
N2 - We review the structure, cellular distribution, ligand specificity, and function of two emerging types of receptors involved in natural killer (NK) and myeloid cell recognition of other cells: ILT/LIR/MIR and 2B4 receptors. ILT/LIR/MIR receptors are differentially expressed on lymphoid and myeloid cells and two of them, ILT2 and ILT4, recognize HLA class I molecules. Whereas some receptors inhibit, others induce cell activation. 2B4 is broadly expressed on leukocytes, binds CD48, and mediates non-MHC-restricted cytotoxicity by NK cells.
AB - We review the structure, cellular distribution, ligand specificity, and function of two emerging types of receptors involved in natural killer (NK) and myeloid cell recognition of other cells: ILT/LIR/MIR and 2B4 receptors. ILT/LIR/MIR receptors are differentially expressed on lymphoid and myeloid cells and two of them, ILT2 and ILT4, recognize HLA class I molecules. Whereas some receptors inhibit, others induce cell activation. 2B4 is broadly expressed on leukocytes, binds CD48, and mediates non-MHC-restricted cytotoxicity by NK cells.
KW - Basophils
KW - CD48
KW - Cell sulface molecules
KW - Dendritic cells
KW - Immunoglobulin superfamily
KW - Major histocompatibility complex
KW - Monocytes/macrophages
UR - http://www.scopus.com/inward/record.url?scp=0032758440&partnerID=8YFLogxK
U2 - 10.1002/jlb.66.5.718
DO - 10.1002/jlb.66.5.718
M3 - Article
C2 - 10577499
AN - SCOPUS:0032758440
SN - 0741-5400
VL - 66
SP - 718
EP - 722
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 5
ER -