We review the structure, cellular distribution, ligand specificity, and function of two emerging types of receptors involved in natural killer (NK) and myeloid cell recognition of other cells: ILT/LIR/MIR and 2B4 receptors. ILT/LIR/MIR receptors are differentially expressed on lymphoid and myeloid cells and two of them, ILT2 and ILT4, recognize HLA class I molecules. Whereas some receptors inhibit, others induce cell activation. 2B4 is broadly expressed on leukocytes, binds CD48, and mediates non-MHC-restricted cytotoxicity by NK cells.

Original languageEnglish
Pages (from-to)718-722
Number of pages5
JournalJournal of Leukocyte Biology
Issue number5
StatePublished - 1999


  • Basophils
  • CD48
  • Cell sulface molecules
  • Dendritic cells
  • Immunoglobulin superfamily
  • Major histocompatibility complex
  • Monocytes/macrophages


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