Inhibition of the G2 DNA damage checkpoint by oliveroline isolated from Duguetia odorata

Harry C. Brastianos; Christopher M. Sturgeon; Michel Roberge; Raymond J. Andersen

doi:10.1021/np060285e

Inhibition of the G₂ DNA damage checkpoint by oliveroline isolated from Duguetia odorata

Harry C. Brastianos
, Christopher M. Sturgeon
, Michel Roberge
, Raymond J. Andersen

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Plant extracts obtained from the U.S. National Cancer Institute's Open Repository collection have been screened for their ability to inhibit the G ₂ DNA damage checkpoint. An extract of Duguetia odorata showed promising activity in the assay. Bioassay-guided fractionation revealed that oliveroline (1) was responsible for the G₂ checkpoint inhibitory activity of the D. odorata extract. The new alkaloid JV-methylguatterine (2) was identified during this investigation.

Original language	English
Pages (from-to)	287-288
Number of pages	2
Journal	Journal of Natural Products
Volume	70
Issue number	2
DOIs	https://doi.org/10.1021/np060285e
State	Published - Feb 2007
Externally published	Yes

Access to Document

10.1021/np060285e

Cite this

@article{b539c28ba835446381cf25ef9cb80a05,

title = "Inhibition of the G2 DNA damage checkpoint by oliveroline isolated from Duguetia odorata",

abstract = "Plant extracts obtained from the U.S. National Cancer Institute's Open Repository collection have been screened for their ability to inhibit the G 2 DNA damage checkpoint. An extract of Duguetia odorata showed promising activity in the assay. Bioassay-guided fractionation revealed that oliveroline (1) was responsible for the G2 checkpoint inhibitory activity of the D. odorata extract. The new alkaloid JV-methylguatterine (2) was identified during this investigation.",

author = "Brastianos, \{Harry C.\} and Sturgeon, \{Christopher M.\} and Michel Roberge and Andersen, \{Raymond J.\}",

year = "2007",

month = feb,

doi = "10.1021/np060285e",

language = "English",

volume = "70",

pages = "287--288",

journal = "Journal of Natural Products",

issn = "0163-3864",

number = "2",

}

TY - JOUR

T1 - Inhibition of the G2 DNA damage checkpoint by oliveroline isolated from Duguetia odorata

AU - Brastianos, Harry C.

AU - Sturgeon, Christopher M.

AU - Roberge, Michel

AU - Andersen, Raymond J.

PY - 2007/2

Y1 - 2007/2

N2 - Plant extracts obtained from the U.S. National Cancer Institute's Open Repository collection have been screened for their ability to inhibit the G 2 DNA damage checkpoint. An extract of Duguetia odorata showed promising activity in the assay. Bioassay-guided fractionation revealed that oliveroline (1) was responsible for the G2 checkpoint inhibitory activity of the D. odorata extract. The new alkaloid JV-methylguatterine (2) was identified during this investigation.

AB - Plant extracts obtained from the U.S. National Cancer Institute's Open Repository collection have been screened for their ability to inhibit the G 2 DNA damage checkpoint. An extract of Duguetia odorata showed promising activity in the assay. Bioassay-guided fractionation revealed that oliveroline (1) was responsible for the G2 checkpoint inhibitory activity of the D. odorata extract. The new alkaloid JV-methylguatterine (2) was identified during this investigation.

UR - https://www.scopus.com/pages/publications/33947399148

U2 - 10.1021/np060285e

DO - 10.1021/np060285e

M3 - Article

C2 - 17315964

AN - SCOPUS:33947399148

SN - 0163-3864

VL - 70

SP - 287

EP - 288

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 2

ER -

Inhibition of the G₂ DNA damage checkpoint by oliveroline isolated from Duguetia odorata

Abstract

Access to Document

Other files and links

Fingerprint

Cite this