The inhibition of 5-[3H] hydroxytryptamine uptake into rat forebrain synaptosomes by human plasma extracts was studied. Highly potent, small (Mr < 10000), and heat stable factor(s) were found to inhibit 5-[3H] hydroxytryptamine uptake specifically, reversibly and in a non-competitive manner. The possible role of these factor(s) as endogenous modulators of serotonergic activity is discussed.
|Number of pages||5|
|State||Published - Jun 11 1984|
- 5-Hydroxytryptamine uptake
- Endogenous modulator
- Plasma factor