Inhibition of synaptosomal 5-[3H]hydroxytryptamine uptake by endogenous factor(s) in human blood

Itzchak Angel; Steven M. Paul

doi:10.1016/0014-5793(84)80504-9

Inhibition of synaptosomal 5-[³H]hydroxytryptamine uptake by endogenous factor(s) in human blood

Itzchak Angel, Steven M. Paul

Washington University School of Medicine

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

The inhibition of 5-[³H] hydroxytryptamine uptake into rat forebrain synaptosomes by human plasma extracts was studied. Highly potent, small (M_r < 10000), and heat stable factor(s) were found to inhibit 5-[³H] hydroxytryptamine uptake specifically, reversibly and in a non-competitive manner. The possible role of these factor(s) as endogenous modulators of serotonergic activity is discussed.

Original language	English
Pages (from-to)	280-284
Number of pages	5
Journal	FEBS Letters
Volume	171
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(84)80504-9
State	Published - Jun 11 1984

Keywords

5-Hydroxytryptamine uptake
Endogenous modulator
Imipramine
Plasma factor
Synaptosome

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10.1016/0014-5793(84)80504-9

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abstract = "The inhibition of 5-[3H] hydroxytryptamine uptake into rat forebrain synaptosomes by human plasma extracts was studied. Highly potent, small (Mr < 10000), and heat stable factor(s) were found to inhibit 5-[3H] hydroxytryptamine uptake specifically, reversibly and in a non-competitive manner. The possible role of these factor(s) as endogenous modulators of serotonergic activity is discussed.",

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N2 - The inhibition of 5-[3H] hydroxytryptamine uptake into rat forebrain synaptosomes by human plasma extracts was studied. Highly potent, small (Mr < 10000), and heat stable factor(s) were found to inhibit 5-[3H] hydroxytryptamine uptake specifically, reversibly and in a non-competitive manner. The possible role of these factor(s) as endogenous modulators of serotonergic activity is discussed.

AB - The inhibition of 5-[3H] hydroxytryptamine uptake into rat forebrain synaptosomes by human plasma extracts was studied. Highly potent, small (Mr < 10000), and heat stable factor(s) were found to inhibit 5-[3H] hydroxytryptamine uptake specifically, reversibly and in a non-competitive manner. The possible role of these factor(s) as endogenous modulators of serotonergic activity is discussed.

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KW - Endogenous modulator

KW - Imipramine

KW - Plasma factor

KW - Synaptosome

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Inhibition of synaptosomal 5-[³H]hydroxytryptamine uptake by endogenous factor(s) in human blood

Abstract

Keywords

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