Inhibition of synaptosomal 5-[3H]hydroxytryptamine uptake by endogenous factor(s) in human blood

Itzchak Angel, Steven M. Paul

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

The inhibition of 5-[3H] hydroxytryptamine uptake into rat forebrain synaptosomes by human plasma extracts was studied. Highly potent, small (Mr < 10000), and heat stable factor(s) were found to inhibit 5-[3H] hydroxytryptamine uptake specifically, reversibly and in a non-competitive manner. The possible role of these factor(s) as endogenous modulators of serotonergic activity is discussed.

Original languageEnglish
Pages (from-to)280-284
Number of pages5
JournalFEBS Letters
Volume171
Issue number2
DOIs
StatePublished - Jun 11 1984
Externally publishedYes

Keywords

  • 5-Hydroxytryptamine uptake
  • Endogenous modulator
  • Imipramine
  • Plasma factor
  • Synaptosome

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