Abstract: The binding of [3H]diazepam and [3H]3‐carboethoxy‐β‐carboline was examined in rat brain synaptosomal membranes treated with irazepine, an alkylating benzodiazepine. Under incubation conditions that resulted in a 25–33% reduction in the Bmax of [3H]diazepam binding, only modest (<8.5%) reductions in the Bmax of [3H]3‐carboethoxy‐β‐carboline were observed. The differential effects of irazepine on the binding of these two compounds may be explained by the presence of multiple areas or “domains” on the benzodiazepine receptor.
|Number of pages||5|
|Journal||Journal of Neurochemistry|
|State||Published - Oct 1982|
- Benzodiazepine receptor