Inhibition of [3H]Diazepam and [3H]3‐Carboethoxy‐β‐Carboline Binding by Irazepine: Evidence for Multiple “Domains” of the Benzodiazepine Receptor

Phil Skolnick, Margaret Schweri, Eberhard Kutter, Evan Williams, Steven Paul

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Abstract: The binding of [3H]diazepam and [3H]3‐carboethoxy‐β‐carboline was examined in rat brain synaptosomal membranes treated with irazepine, an alkylating benzodiazepine. Under incubation conditions that resulted in a 25–33% reduction in the Bmax of [3H]diazepam binding, only modest (<8.5%) reductions in the Bmax of [3H]3‐carboethoxy‐β‐carboline were observed. The differential effects of irazepine on the binding of these two compounds may be explained by the presence of multiple areas or “domains” on the benzodiazepine receptor.

Original languageEnglish
Pages (from-to)1142-1146
Number of pages5
JournalJournal of Neurochemistry
Volume39
Issue number4
DOIs
StatePublished - Oct 1982

Keywords

  • 3‐Carboethoxy
  • Benzodiazepine receptor
  • Diazepam
  • Domain
  • Irazepine
  • β‐carboline

Fingerprint

Dive into the research topics of 'Inhibition of [3H]Diazepam and [3H]3‐Carboethoxy‐β‐Carboline Binding by Irazepine: Evidence for Multiple “Domains” of the Benzodiazepine Receptor'. Together they form a unique fingerprint.

Cite this