Inhibition of spontaneous akr leukemia by multiple inoculations of Corynebacterium parvum

Jerome H. Check; Gary A. Silverman; Richard L. Dryden; Luther W. Brady

doi:10.1002/1097-0142(197908)44:2<488::AID-CNCR2820440218>3.0.CO;2-H

Inhibition of spontaneous akr leukemia by multiple inoculations of Corynebacterium parvum

Jerome H. Check, Gary A. Silverman, Richard L. Dryden, Luther W. Brady

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Abstract

In previous studies we have shown that AKR mice could be protected from spontaneous leukemia by specific immunotherapy in combination with splenectomy. In this experiment we investigated the effects of nonspecific immunotherapy with C. parvum in a similar regimen. It was found that bi‐weekly, ip inoculations of 0.7 mg of C. parvum could significantly protect AKR mice from spontaneous tumors, and that splenectomy could not modify this effect. Thus, the spleen does not appear to play a determinant role in mediating the protective effects of C. parvum, as had been suggested in other systems. Cancer 44:488‐491, 1979.

Original language	English
Pages (from-to)	488-491
Number of pages	4
Journal	Cancer
Volume	44
Issue number	2
DOIs	https://doi.org/10.1002/1097-0142(197908)44:2<488::AID-CNCR2820440218>3.0.CO;2-H
State	Published - Aug 1979

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10.1002/1097-0142(197908)44:2<488::AID-CNCR2820440218>3.0.CO;2-H

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title = "Inhibition of spontaneous akr leukemia by multiple inoculations of Corynebacterium parvum",

abstract = "In previous studies we have shown that AKR mice could be protected from spontaneous leukemia by specific immunotherapy in combination with splenectomy. In this experiment we investigated the effects of nonspecific immunotherapy with C. parvum in a similar regimen. It was found that bi‐weekly, ip inoculations of 0.7 mg of C. parvum could significantly protect AKR mice from spontaneous tumors, and that splenectomy could not modify this effect. Thus, the spleen does not appear to play a determinant role in mediating the protective effects of C. parvum, as had been suggested in other systems. Cancer 44:488‐491, 1979.",

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AU - Brady, Luther W.

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N2 - In previous studies we have shown that AKR mice could be protected from spontaneous leukemia by specific immunotherapy in combination with splenectomy. In this experiment we investigated the effects of nonspecific immunotherapy with C. parvum in a similar regimen. It was found that bi‐weekly, ip inoculations of 0.7 mg of C. parvum could significantly protect AKR mice from spontaneous tumors, and that splenectomy could not modify this effect. Thus, the spleen does not appear to play a determinant role in mediating the protective effects of C. parvum, as had been suggested in other systems. Cancer 44:488‐491, 1979.

AB - In previous studies we have shown that AKR mice could be protected from spontaneous leukemia by specific immunotherapy in combination with splenectomy. In this experiment we investigated the effects of nonspecific immunotherapy with C. parvum in a similar regimen. It was found that bi‐weekly, ip inoculations of 0.7 mg of C. parvum could significantly protect AKR mice from spontaneous tumors, and that splenectomy could not modify this effect. Thus, the spleen does not appear to play a determinant role in mediating the protective effects of C. parvum, as had been suggested in other systems. Cancer 44:488‐491, 1979.

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Inhibition of spontaneous akr leukemia by multiple inoculations of Corynebacterium parvum

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