Abstract
The respiratory syncytial virus (RSV) fusion glycoprotein (F) can interact with the small intracellular GTPase RhoA, and peptides derived from RhoA inhibit RSV replication. These observations initially suggested that RhoA-derived peptides might inhibit RSV replication by disrupting an in vivo interaction between RSV F and RhoA. However, recent data indicate that the antiviral activity of RhoA-derived peptides is not due to competitive inhibition of an hypothesized F-RhoA interaction, but is rather a function of the peptides' intrinsic biophysical properties. We summarize here what is known about the mechanism of RSV inhibition by these peptides and give our opinion regarding the potential implications of this work with regards to RSV biology, and to the development of antiviral agents targeting RSV and other enveloped viruses.
Original language | English |
---|---|
Pages (from-to) | 299-302 |
Number of pages | 4 |
Journal | Journal of Antimicrobial Chemotherapy |
Volume | 54 |
Issue number | 2 |
DOIs | |
State | Published - Aug 2004 |
Keywords
- Antiviral agents
- Dextran sulphate
- Fusion inhibition
- HIV
- Heparan sulphate
- Heparin
- Human immunodeficiency virus
- Polyanions
- Post-attachment neutralization
- RSV
- Sulphated polysaccharides