Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

Keyphrases

• Gain-of-function 100%
• Polycomb Repressive Complex 2 (PRC2) 100%
• H3K27M 100%
• Pediatric Glioblastoma 100%
• H3K27me3 66%
• Lysine 66%
• Histone 33%
• Histone H3 33%
• Enzymatic Activity 33%
• Enhancer of Zeste Homolog 2 (EZH2) 33%
• SET Domain 33%
• H3K36me3 33%
• Cause-specific 33%
• Missense mutation 33%
• Methylation 33%
• Epigenetic State 33%
• H3F3A 33%
• Pediatric Glioma 33%
• Diffuse Intrinsic Pontine Glioma 33%
• H3K9me3 33%
• H3.1 33%
• Methylated Lysine 33%
• Methionine Substitution 33%
• K27M mutation 33%

Biochemistry, Genetics and Molecular Biology

• PRC2 100%
• Lysine 100%
• Transgene 66%
• Histone 66%
• Epigenetics 33%
• Enzyme 33%
• Enzyme Activity 33%
• EZH2 33%
• SET Domain 33%
• Missense Mutation 33%
• Methylation 33%
• H3F3A 33%
• Polycomb Repressive Complex 2 33%
• Methionine 33%