Background: Glucose activates CaMKII in β-cells, how this influences glucose homeostasis has not been determined. Results: Inhibiting CaMKII in mouse β-cells causes glucose intolerance by reducing Ca2+ entry and insulin secretion. Conclusion: CaMKII is a β-cell Ca2+ sensor that amplifies secretagogue-induced Ca2+ entry and insulin secretion to maintain glucose homeostasis. Significance: This provides the first evidence that β-cell CaMKII modulates glucose homeostasis under physiological and insulin resistant states.

Original languageEnglish
Pages (from-to)12435-12445
Number of pages11
JournalJournal of Biological Chemistry
Issue number18
StatePublished - 2014


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