Abstract
Background: Glucose activates CaMKII in β-cells, how this influences glucose homeostasis has not been determined. Results: Inhibiting CaMKII in mouse β-cells causes glucose intolerance by reducing Ca2+ entry and insulin secretion. Conclusion: CaMKII is a β-cell Ca2+ sensor that amplifies secretagogue-induced Ca2+ entry and insulin secretion to maintain glucose homeostasis. Significance: This provides the first evidence that β-cell CaMKII modulates glucose homeostasis under physiological and insulin resistant states.
Original language | English |
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Pages (from-to) | 12435-12445 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 18 |
DOIs | |
State | Published - 2014 |