Background: Glucose activates CaMKII in β-cells, how this influences glucose homeostasis has not been determined. Results: Inhibiting CaMKII in mouse β-cells causes glucose intolerance by reducing Ca2+ entry and insulin secretion. Conclusion: CaMKII is a β-cell Ca2+ sensor that amplifies secretagogue-induced Ca2+ entry and insulin secretion to maintain glucose homeostasis. Significance: This provides the first evidence that β-cell CaMKII modulates glucose homeostasis under physiological and insulin resistant states.
|Number of pages||11|
|Journal||Journal of Biological Chemistry|
|State||Published - 2014|