Abstract
In this study, the auditory bulla of the gerbil was pressurized, leading to active modeling of the bone of the bulla wall with a significant increase in osteoclast surface and mineral apposition rate. Systemic infusion of L- N(G)-nitro-arginine-methyl ester (L-NAME), an inhibitor of nitric oxide synthase (NOS), inhibited this modeling process. The percentage osteoclast surface (Oc.S/BS) on the inner surface bulla wall was significantly reduced in the L-NAME-treated animals when compared with pressurized saline-treated bullae. Fluorescent bone surface (BS(f)) mineral apposition rates (MAR) and bone formation rate (BFR) were not significantly different in the pressurized bullae when the L-NAME group was compared with the control (vehicle only) group. However, L-NAME significantly suppressed BS(f) in the unpressurized bullae. Therefore, it is likely that nitric oxide is a mediator of osteoclastic resorption due to adaptive bone modeling through one or more of the isoforms of NOS.
Original language | English |
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Pages (from-to) | 705-711 |
Number of pages | 7 |
Journal | Acta Oto-Laryngologica |
Volume | 118 |
Issue number | 5 |
DOIs | |
State | Published - 1998 |
Keywords
- Bone resorption
- Gerbil
- L-NAME
- Nitric oxide
- Nitric oxide synthase
- Osteoclast