Inhibition of nitric oxide synthase blocks osteoclastic bone resorption in adaptive bone modeling

Richard A. Chole, Steven P. Tinling, Erin Leverentz, Michael D. McGinn

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

In this study, the auditory bulla of the gerbil was pressurized, leading to active modeling of the bone of the bulla wall with a significant increase in osteoclast surface and mineral apposition rate. Systemic infusion of L- N(G)-nitro-arginine-methyl ester (L-NAME), an inhibitor of nitric oxide synthase (NOS), inhibited this modeling process. The percentage osteoclast surface (Oc.S/BS) on the inner surface bulla wall was significantly reduced in the L-NAME-treated animals when compared with pressurized saline-treated bullae. Fluorescent bone surface (BS(f)) mineral apposition rates (MAR) and bone formation rate (BFR) were not significantly different in the pressurized bullae when the L-NAME group was compared with the control (vehicle only) group. However, L-NAME significantly suppressed BS(f) in the unpressurized bullae. Therefore, it is likely that nitric oxide is a mediator of osteoclastic resorption due to adaptive bone modeling through one or more of the isoforms of NOS.

Original languageEnglish
Pages (from-to)705-711
Number of pages7
JournalActa Oto-Laryngologica
Volume118
Issue number5
DOIs
StatePublished - Nov 17 1998

Keywords

  • Bone resorption
  • Gerbil
  • L-NAME
  • Nitric oxide
  • Nitric oxide synthase
  • Osteoclast

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