Objective-The goal of this study was to determine whether antagonizing microRNA (miR)-29 enhances elastin (ELN) levels in cells and tissues lacking ELN. Methods and Results-miR-29 mimics reduced ELN levels in fibroblasts and smooth muscle cells, whereas miR-29 inhibition increased ELN levels. Antagonism of miR-29 also increased ELN levels in cells from patients haploinsufficient for ELN and in bioengineered human vessels. Conclusion-miR-29 antagonism may promote increased ELN levels during conditions of ELN deficiencies.
|Number of pages||4|
|Journal||Arteriosclerosis, thrombosis, and vascular biology|
|State||Published - Mar 2012|
- extracellular matrix