Inhibition of MicroRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels-brief report

Pei Zhang, Angela Huang, Jacopo Ferruzzi, Robert P. Mecham, Barry C. Starcher, George Tellides, Jay D. Humphrey, Frank J. Giordano, Laura E. Niklason, William C. Sessa

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Objective-The goal of this study was to determine whether antagonizing microRNA (miR)-29 enhances elastin (ELN) levels in cells and tissues lacking ELN. Methods and Results-miR-29 mimics reduced ELN levels in fibroblasts and smooth muscle cells, whereas miR-29 inhibition increased ELN levels. Antagonism of miR-29 also increased ELN levels in cells from patients haploinsufficient for ELN and in bioengineered human vessels. Conclusion-miR-29 antagonism may promote increased ELN levels during conditions of ELN deficiencies.

Original languageEnglish
Pages (from-to)756-759
Number of pages4
JournalArteriosclerosis, thrombosis, and vascular biology
Volume32
Issue number3
DOIs
StatePublished - Mar 2012

Keywords

  • aneurysms
  • extracellular matrix
  • microRNA

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