Inhibition of MicroRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels-brief report

Pei Zhang; Angela Huang; Jacopo Ferruzzi; Robert P. Mecham; Barry C. Starcher; George Tellides; Jay D. Humphrey; Frank J. Giordano; Laura E. Niklason; William C. Sessa

doi:10.1161/ATVBAHA.111.238113

Inhibition of MicroRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels-brief report

Pei Zhang, Angela Huang, Jacopo Ferruzzi, Robert P. Mecham, Barry C. Starcher, George Tellides, Jay D. Humphrey, Frank J. Giordano, Laura E. Niklason, William C. Sessa

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91 Scopus citations

Abstract

Objective-The goal of this study was to determine whether antagonizing microRNA (miR)-29 enhances elastin (ELN) levels in cells and tissues lacking ELN. Methods and Results-miR-29 mimics reduced ELN levels in fibroblasts and smooth muscle cells, whereas miR-29 inhibition increased ELN levels. Antagonism of miR-29 also increased ELN levels in cells from patients haploinsufficient for ELN and in bioengineered human vessels. Conclusion-miR-29 antagonism may promote increased ELN levels during conditions of ELN deficiencies.

Original language	English
Pages (from-to)	756-759
Number of pages	4
Journal	Arteriosclerosis, thrombosis, and vascular biology
Volume	32
Issue number	3
DOIs	https://doi.org/10.1161/ATVBAHA.111.238113
State	Published - Mar 2012

Keywords

aneurysms
extracellular matrix
microRNA

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10.1161/ATVBAHA.111.238113

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Zhang, P., Huang, A., Ferruzzi, J., Mecham, R. P., Starcher, B. C., Tellides, G., Humphrey, J. D., Giordano, F. J., Niklason, L. E., & Sessa, W. C. (2012). Inhibition of MicroRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels-brief report. Arteriosclerosis, thrombosis, and vascular biology, 32(3), 756-759. https://doi.org/10.1161/ATVBAHA.111.238113

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title = "Inhibition of MicroRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels-brief report",

abstract = "Objective-The goal of this study was to determine whether antagonizing microRNA (miR)-29 enhances elastin (ELN) levels in cells and tissues lacking ELN. Methods and Results-miR-29 mimics reduced ELN levels in fibroblasts and smooth muscle cells, whereas miR-29 inhibition increased ELN levels. Antagonism of miR-29 also increased ELN levels in cells from patients haploinsufficient for ELN and in bioengineered human vessels. Conclusion-miR-29 antagonism may promote increased ELN levels during conditions of ELN deficiencies.",

keywords = "aneurysms, extracellular matrix, microRNA",

author = "Pei Zhang and Angela Huang and Jacopo Ferruzzi and Mecham, {Robert P.} and Starcher, {Barry C.} and George Tellides and Humphrey, {Jay D.} and Giordano, {Frank J.} and Niklason, {Laura E.} and Sessa, {William C.}",

year = "2012",

month = mar,

doi = "10.1161/ATVBAHA.111.238113",

language = "English",

volume = "32",

pages = "756--759",

journal = "Arteriosclerosis, thrombosis, and vascular biology",

issn = "1079-5642",

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Zhang, P, Huang, A, Ferruzzi, J, Mecham, RP, Starcher, BC, Tellides, G, Humphrey, JD, Giordano, FJ, Niklason, LE & Sessa, WC 2012, 'Inhibition of MicroRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels-brief report', Arteriosclerosis, thrombosis, and vascular biology, vol. 32, no. 3, pp. 756-759. https://doi.org/10.1161/ATVBAHA.111.238113

TY - JOUR

T1 - Inhibition of MicroRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels-brief report

AU - Zhang, Pei

AU - Huang, Angela

AU - Ferruzzi, Jacopo

AU - Mecham, Robert P.

AU - Starcher, Barry C.

AU - Tellides, George

AU - Humphrey, Jay D.

AU - Giordano, Frank J.

AU - Niklason, Laura E.

AU - Sessa, William C.

PY - 2012/3

Y1 - 2012/3

N2 - Objective-The goal of this study was to determine whether antagonizing microRNA (miR)-29 enhances elastin (ELN) levels in cells and tissues lacking ELN. Methods and Results-miR-29 mimics reduced ELN levels in fibroblasts and smooth muscle cells, whereas miR-29 inhibition increased ELN levels. Antagonism of miR-29 also increased ELN levels in cells from patients haploinsufficient for ELN and in bioengineered human vessels. Conclusion-miR-29 antagonism may promote increased ELN levels during conditions of ELN deficiencies.

AB - Objective-The goal of this study was to determine whether antagonizing microRNA (miR)-29 enhances elastin (ELN) levels in cells and tissues lacking ELN. Methods and Results-miR-29 mimics reduced ELN levels in fibroblasts and smooth muscle cells, whereas miR-29 inhibition increased ELN levels. Antagonism of miR-29 also increased ELN levels in cells from patients haploinsufficient for ELN and in bioengineered human vessels. Conclusion-miR-29 antagonism may promote increased ELN levels during conditions of ELN deficiencies.

KW - aneurysms

KW - extracellular matrix

KW - microRNA

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U2 - 10.1161/ATVBAHA.111.238113

DO - 10.1161/ATVBAHA.111.238113

M3 - Article

C2 - 22095981

AN - SCOPUS:84857558503

SN - 1079-5642

VL - 32

SP - 756

EP - 759

JO - Arteriosclerosis, thrombosis, and vascular biology

JF - Arteriosclerosis, thrombosis, and vascular biology

IS - 3

ER -

Inhibition of MicroRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels-brief report

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Keywords

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