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Keyphrases
Mouse Model
100%
Gene-deficient Mice
100%
Disease Process
100%
Aortic Valve Disease
100%
Aortic Valve
80%
Refametinib
80%
Doxycycline
60%
Elastase
40%
Elastic Fibers
40%
Fiber Fabrication
40%
ERK Pathway
40%
Valve Tissue
40%
Elastic Fiber Fragmentation
40%
Disease Progression
20%
RNA-seq Analysis
20%
Targeted Therapy
20%
Fibrosis
20%
Inflammatory Pathways
20%
Glycoprotein
20%
Treatment Strategy
20%
ERK2
20%
Pharmacological Inhibitors
20%
Natural History
20%
Promising Treatment
20%
Assembly Error
20%
Neutrophil Infiltration
20%
MEK1
20%
ERK Activation
20%
Matrix metalloproteinase-9 (MMP-9)
20%
Neovascularization
20%
Elastase Activity
20%
Elastolytic Activity
20%
Abnormal Angiogenesis
20%
Adult Stage
20%
Macrophage Infiltration
20%
Cathepsin K
20%
Matrix metalloproteinase-2 (MMP-2)
20%
Elastase Inhibitor
20%
Age-matched
20%
Type Control
20%
Pharmacologic Treatment
20%
Anti-VEGF-A
20%
Medicine and Dentistry
Disease Process
100%
Mitogen-Activated Protein Kinase
100%
Aortic Valve Disease
100%
Aortic Valve
80%
Elastic Fiber
80%
Refametinib
80%
Doxycycline
60%
Elastase
60%
Upregulation
20%
Macrophage
20%
Targeted Therapy
20%
Fibrosis
20%
Disease Exacerbation
20%
Angiogenesis
20%
Neutrophil Chemotaxis
20%
Gelatinase B
20%
Glycoprotein
20%
Vasculotropin A
20%
Gelatinase A
20%
Elastase Inhibitor
20%
Cathepsin K
20%
Biochemistry, Genetics and Molecular Biology
Mitogen-Activated Protein Kinase
100%
Mouse Model
100%
Elastase
100%
Elastic Fiber
100%
Upregulation
25%
Wild Type
25%
Neutrophil Chemotaxis
25%
Angiogenesis
25%
Glycoprotein
25%
Macrophage
25%
Gelatinase B
25%
MMP9
25%
Neovascularization (Pathology)
25%
Gelatinase A
25%
MMP2
25%
Cathepsin K
25%
Vascular Endothelial Growth Factor A
25%
Targeted Therapy
25%
Pharmacology, Toxicology and Pharmaceutical Science
Mouse Model
100%
Aortic Valve Disease
100%
Refametinib
80%
Doxycycline
60%
Elastase
60%
Fibrosis
20%
Disease Exacerbation
20%
Glycoprotein
20%
Gelatinase B
20%
Neovascularization (Pathology)
20%
Gelatinase A
20%
Elastase Inhibitor
20%
Vasculotropin A
20%
Cathepsin K
20%
Immunology and Microbiology
Mouse Model
100%
Aortic Valve
100%
Elastic Fiber
44%
Wild Type
11%
Neutrophil Chemotaxis
11%
Macrophage
11%
Angiogenesis
11%
Glycoprotein
11%
Upregulation
11%
Neovascularization (Pathology)
11%
Vasculotropin A
11%