Inhibition of growth and appearance of estrogen-dependent rat mammary tumors by 10-propargylestr-4-ene-3,17-dione, an aromatase inhibitor

S. J. Zimniski, M. E. Brandt, D. F. Covey, D. Puett

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The aromatase inhibitor 10-propargylestr-4-ene-3,17-dione (PED) has been evaluated in vivo as an anticancer agent. Prolonged administration of PED to rats bearing dimethylbenzanthracene-induced mammary tumors resulted in significant regression of hormone-responsive tumors within several days. Greater than 50% regression was generally observed after 14 days of treatment, irrespective of dose (1, 5, or 50mg/kg body weight/day). In addition to tumor regression, a significantly increased incidence in tumor stasis was observed over the course of PED treatment. While all doses of PED examined were equipotent for both tumor regression and stasis, a dose-dependent inhibition of new tumor formation was observed in PED-treated rats. In control animals an average of 1.2 new tumors was observed during the experimental period; in contrast, averages of 0.5 tumors appeared in animals receiving 1mg PED/kg body weight/day, 0.1 tumors at 5 mg/kg, and at 50mg of PED/kg body weight/day, no new tumors occurred during the time PED was administered. The effects of PED on both regression of existing tumors and appearance of new tumors were reversed by co-administration of estradiol. Thus, PED impairs estrogen-dependent mammary tumor growth, resulting in cessation of new growth and regression of responsive tumors.

Original languageEnglish
Pages (from-to)15-21
Number of pages7
JournalBreast Cancer Research and Treatment
Volume26
Issue number1
DOIs
StatePublished - Jan 1993

Keywords

  • aromatase
  • aromatase inhibitors
  • breast cancer
  • estrogen
  • estrous cycle
  • tumor regression

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