Inhibition of foxo1 protects pancreatic islet β-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis

Keyphrases

• Fatty Acids 100%
• Pancreatic Islet Cells 100%
• Forkhead Box O1 (FOXO1) 100%
• Endoplasmic Reticulum Stress-induced Apoptosis 100%
• Endoplasmic Reticulum Stress (ER stress) 50%
• Acid Activation 41%
• 2-terminal 33%
• Apoptosis 25%
• Dominant Negative 25%
• Induced Apoptosis 25%
• Cell Survival 16%
• Kinase Inhibition 16%
• Stress Markers 16%
• Adenovirus 8%
• Kinase Activation 8%
• Signaling Pathway 8%
• Palmitate 8%
• Type 2 Diabetes Mellitus (T2DM) 8%
• Inducer 8%
• Stress-induced 8%
• Mouse Cells 8%
• Fatty Acid Composition 8%
• Oleate 8%
• Insulin Signaling 8%
• Microarray Analysis 8%
• Putative Drug Targets 8%
• Nuclear Localization 8%
• Pro-apoptotic 8%
• Insulinoma 8%
• CCAAT/enhancer-binding Protein Homologous Protein 8%
• Insulin Receptor 8%
• Mediating Effect 8%
• Stress Kinases 8%
• Phosphatidylinositol 3-kinase/Akt Signaling 8%
• MIN6 Cells 8%
• Transcription Factor CHOP 8%
• Acid Induction 8%
• Induction of Gene Expression 8%

Biochemistry, Genetics and Molecular Biology

• Endoplasmic Reticulum Stress 100%
• Programmed Cell Death 100%
• Kinase 57%
• Phosphotransferase 57%
• Cell Survival 28%
• Gene Expression 14%
• Adenoviridae 14%
• Allele 14%
• Phosphoinositide 3-Kinase 14%
• Insulin Receptor 14%
• Akt Signaling 14%
• Insulin Signaling 14%
• Ccaat-Enhancer-Binding Proteins 14%
• Protein Kinase B 14%
• Stress Kinase 14%
• DNA Damage-Inducible Transcript 3 14%
• Palmitic Acid 14%