Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling

Keyphrases

• Palmitoylation 100%
• EGFR Signaling 100%
• C-terminal Tail 50%
• Cysteine Residues 50%
• Signaling Activation 25%
• Palmitate 25%
• Vulnerability 25%
• Receptor Tyrosine Kinase 25%
• Plasma Membrane 25%
• Mass Spectrometry 25%
• Cell Transformation 25%
• Human Malignancies 25%
• Cell Migration 25%
• EGFR Inhibitors 25%
• Signal Loss 25%
• Induced Cell Death 25%
• EGFR Transactivation 25%
• Signaling Regulation 25%
• Reversible Modification 25%
• Tyrosine Kinase Inhibition 25%
• Cancer Cell Survival 25%
• Palmitoyltransferase 25%
• EGFR Tyrosine Kinase 25%

Biochemistry, Genetics and Molecular Biology

• Epidermal Growth Factor Receptor 100%
• Palmitoylation 100%
• C-Terminus 16%
• Receptor Tyrosine Kinase 16%
• Cysteine 16%
• Cancer Cell 8%
• Cell Membrane 8%
• Tyrosine Kinase 8%
• Mass Spectrometry 8%
• Cell Death 8%
• Cell Survival 8%
• Cell Transformation 8%
• Cell Migration 8%
• Alanine 8%
• Palmitic Acid 8%