Inhibition of dendritic cell maturation by herpes simplex virus

Mariolina Salio, Marina Cella, Mark Suter, Antonio Lanzavecchia

Research output: Contribution to journalArticlepeer-review

324 Scopus citations

Abstract

Maturation of dendritic cells (DC), leading to migration and increased T cell stimulatory capacity, is essential for the initiation of immune responses. This process is triggered by a variety of stimuli, such as inflammatory cytokines, bacterial and viral products. Using a recombinant disabled infectious single cycle herpes simplex virus 1 (HSV-1) encoding green fluorescent protein, we show that the infected DC are defective in up-regulating co-stimulatory molecules, do not produce cytokines, and do not acquire responsiveness to chemokines required for migration to secondary lymphoid organs. These results reveal yet another strategy used by HSV-1 to evade the immune response, namely the inhibition of signaling pathways involved in DC maturation.

Original languageEnglish
Pages (from-to)3245-3253
Number of pages9
JournalEuropean Journal of Immunology
Volume29
Issue number10
DOIs
StatePublished - Oct 26 1999

Keywords

  • Dendritic cell maturation
  • Herpes virus
  • Immunopathology
  • T lymphocyte stimulation

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